WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130439
CAS#: N/A
Description: DU-14, a degrader of both Protein tyrosine phosphatase 1B (PTP1B) and T-cell protein tyrosine phosphatase (TC-PTP), enhances activation of the JAK1/2-STAT1 pathway induced by IFN-γ and promotes the expression of MHC-I in tumor cells, serving as a potential treatment for certain cancers.
Hodoodo Cat#: H130439
Name: DU-14
CAS#: N/A
Chemical Formula: C74H85BrF2N9O14PS
Exact Mass: 1,503.48
Molecular Weight: 1,505.478
Elemental Analysis: C, 59.04; H, 5.69; Br, 5.31; F, 2.52; N, 8.37; O, 14.88; P, 2.06; S, 2.13
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Synonym: DU-14; DU14; DU 14
IUPAC/Chemical Name: ((4-((S)-3-(((S)-6-(3-bromo-4-methylbenzamido)-1-((3-(2-(((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-2-oxoethyl)benzyl)amino)-1-oxohexan-2-yl)amino)-2-((S)-2-(2-(4-hydroxy-3-methoxyphenyl)acetamido)-3-phenylpropanamido)-3-oxopropyl)phenyl)difluoromethyl)phosphonic acid
InChi Key: QZUOSZAORFBNEN-XMZKEKGRSA-N
InChi Code: InChI=1S/C74H85BrF2N9O14PS/c1-43-19-23-53(38-56(43)75)67(91)78-31-12-11-18-57(83-70(94)59(34-47-20-28-54(29-21-47)74(76,77)101(97,98)99)84-69(93)58(33-46-14-9-8-10-15-46)82-63(89)37-49-22-30-61(88)62(35-49)100-7)68(92)79-40-50-17-13-16-48(32-50)36-64(90)85-66(73(4,5)6)72(96)86-41-55(87)39-60(86)71(95)81-44(2)51-24-26-52(27-25-51)65-45(3)80-42-102-65/h8-10,13-17,19-30,32,35,38,42,44,55,57-60,66,87-88H,11-12,18,31,33-34,36-37,39-41H2,1-7H3,(H,78,91)(H,79,92)(H,81,95)(H,82,89)(H,83,94)(H,84,93)(H,85,90)(H2,97,98,99)/t44-,55+,57-,58-,59-,60-,66+/m0/s1
SMILES Code: FC(C1=CC=C(C[C@H](NC([C@@H](NC(CC2=CC=C(O)C(OC)=C2)=O)CC3=CC=CC=C3)=O)C(N[C@@H](CCCCNC(C4=CC=C(C)C(Br)=C4)=O)C(NCC5=CC=CC(CC(N[C@@H](C(C)(C)C)C(N6[C@H](C(N[C@H](C7=CC=C(C8=C(C)N=CS8)C=C7)C)=O)C[C@@H](O)C6)=O)=O)=C5)=O)=O)C=C1)(P(O)(O)=O)F
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 1,505.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Dong J, Miao J, Miao Y, Qu Z, Zhang S, Zhu P, Wiede F, Jassim BA, Bai Y, Nguyen Q, Lin J, Chen L, Tiganis T, Tao WA, Zhang ZY. Small Molecule Degraders of Protein Tyrosine Phosphatase 1B and T-Cell Protein Tyrosine Phosphatase for Cancer Immunotherapy. Angew Chem Int Ed Engl. 2023 Mar 27:e202303818. doi: 10.1002/anie.202303818. Epub ahead of print. PMID: 36973833.