WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130448
CAS#: 2446803-91-2
Description: LP0200 is the prodrug of the oral allosteric IL-17A inactivator.
Hodoodo Cat#: H130448
Name: LP0200
CAS#: 2446803-91-2
Chemical Formula: C28H35N6Na2O6P
Exact Mass: 628.22
Molecular Weight: 628.580
Elemental Analysis: C, 53.50; H, 5.61; N, 13.37; Na, 7.31; O, 15.27; P, 4.93
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Synonym: LP0200; IL-17 modulator 1 disodium
IUPAC/Chemical Name: sodium (S)-(4-(4-(3,3-dicyclopropyl-2-(1-isopropyl-1H-pyrazole-5-carboxamido)propanamido)phenyl)-3,5-dimethyl-1H-pyrazol-1-yl)methyl phosphate
InChi Key: PMFLGFBTYONBAO-ROPHLPQBSA-L
InChi Code: InChI=1S/C28H37N6O6P.2Na/c1-16(2)34-23(13-14-29-34)27(35)31-26(25(20-5-6-20)21-7-8-21)28(36)30-22-11-9-19(10-12-22)24-17(3)32-33(18(24)4)15-40-41(37,38)39;;/h9-14,16,20-21,25-26H,5-8,15H2,1-4H3,(H,30,36)(H,31,35)(H2,37,38,39);;/q;2*+1/p-2/t26-;;/m0../s1
SMILES Code: O=P([O-])([O-])OCN1N=C(C)C(C2=CC=C(NC([C@@H](NC(C3=CC=NN3C(C)C)=O)C(C4CC4)C5CC5)=O)C=C2)=C1C.[Na+].[Na+]
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 628.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Andrews MD, Dack KN, de Groot MJ, Lambert M, Sennbro CJ, Larsen M, Stahlhut M. Discovery of an Oral, Rule of 5 Compliant, Interleukin 17A Protein-Protein Interaction Modulator for the Potential Treatment of Psoriasis and Other Inflammatory Diseases. J Med Chem. 2022 Jul 14;65(13):8828-8842. doi: 10.1021/acs.jmedchem.2c00422. Epub 2022 Jun 29. PMID: 35767390.