WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130446
CAS#: N/A
Description: NP256 is an inhibitor of CaERG6 that has the potential for use as an antifungal. The antifungal activity of NP256 stems from the inhibition ergosterol biosynthesis, the downregulation of the gene expression level in hyphal formation, by blocking biofilm formation, and disrupting morphological transition in C. albicans.
Hodoodo Cat#: H130446
Name: NP256
CAS#: N/A
Chemical Formula: C37H58O8
Exact Mass: 630.41
Molecular Weight: 630.860
Elemental Analysis: C, 70.44; H, 9.27; O, 20.29
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Synonym: NP256; NP 256; NP-256; Palustrisoic acid E
IUPAC/Chemical Name: (2S,6R)-6-((3R,5R,10S,13R,14R,17R)-3-(((S)-4-carboxy-3-hydroxy-3-methylbutanoyl)oxy)-4,4,10,13,14-pentamethyl-2,3,4,5,6,7,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-7-hydroxy-2-methyl-3-methyleneheptanoic acid
InChi Key: WOAOVYIRRFOGFW-VSJVDYLKSA-N
InChi Code: InChI=1S/C37H58O8/c1-22(23(2)32(42)43)9-10-24(21-38)25-13-17-37(8)27-11-12-28-33(3,4)29(45-31(41)20-34(5,44)19-30(39)40)15-16-35(28,6)26(27)14-18-36(25,37)7/h23-25,28-29,38,44H,1,9-21H2,2-8H3,(H,39,40)(H,42,43)/t23-,24-,25+,28-,29+,34-,35+,36+,37-/m0/s1
SMILES Code: O=C(O)[C@@H](C)C(CC[C@H]([C@H]1CC[C@@]2(C)C(CC[C@@]3([H])C(C)(C)[C@H](OC(C[C@@](C)(O)CC(O)=O)=O)CC[C@]43C)=C4CC[C@]12C)CO)=C
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 630.86 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Liu Z, Li Y, Wei D, Wang J, Qiao C, Li GY, Zhang G, Luo Y. Biosensor-Enabled Discovery of CaERG6 Inhibitors and Their Antifungal Mode of Action against Candida albicans. ACS Infect Dis. 2023 Apr 14;9(4):785-800. doi: 10.1021/acsinfecdis.2c00490. Epub 2023 Apr 2. PMID: 37005772.