WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130437
CAS#: 303760-60-3
Description: SLU-PP-332, a ERR pan agonist with the highest affinity for ERRα, has been shown to lead to the increase of mitochondrial function and cellular respiration in a specific skeletal muscle cell line. SLU-PP-332 paves the way for the development of new molecules targeting the ERRα for the treatment of metabolic disorder and serving as a way to improve muscle function in aging.
Hodoodo Cat#: H130437
Name: SLU-PP-332
CAS#: 303760-60-3
Chemical Formula: C18H14N2O2
Exact Mass: 290.11
Molecular Weight: 290.320
Elemental Analysis: Chemical Formula: Exact Mass: Molecular Weight: Elemental Analysis: C, 74.47; H, 4.86; N, 9.65; O, 11.02
Synonym: SLU-PP-332; SLU PP 332
IUPAC/Chemical Name: (E)-4-hydroxy-N'-(naphthalen-2-ylmethylene)benzohydrazide
InChi Key: RNZIMBFHRXYRLL-XDHOZWIPSA-N
InChi Code: InChI=1S/C18H14N2O2/c21-17-9-7-15(8-10-17)18(22)20-19-12-13-5-6-14-3-1-2-4-16(14)11-13/h1-12,21H,(H,20,22)/b19-12+
SMILES Code: O=C(N/N=C/C1=CC=C2C=CC=CC2=C1)C3=CC=C(O)C=C3
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
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The following data is based on the product molecular weight 290.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1. Billon C, Sitaula S, Banerjee S, Welch R, Elgendy B, Hegazy L, Oh TG, Kazantzis M, Chatterjee A, Chrivia J, Hayes ME, Xu W, Hamilton A, Huss JM, Zhang L, Walker JK, Downes M, Evans RM, Burris TP. Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity. ACS Chem Biol. 2023 Apr 21;18(4):756-771. doi: 10.1021/acschembio.2c00720. Epub 2023 Mar 29. PMID: 36988910.
2. https://www.ahajournals.org/doi/10.1161/circ.144.suppl_1.9682
3. https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSM4663186
