WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130436
CAS#: 1144043-83-3
Description: YB-0158 is a β-turn peptidomimetic molecule with high affinity for Sam68, blocking the activity of cancer stem cells, specifically human colorectal cancer stem cells. Cancer stem cells have been postulated to play a role in metastasis and recurrence, with YB-0158 downregulating the transactivation of Wnt, which has been shown to be hyperactivated in cancer stem cells.
Hodoodo Cat#: H130436
Name: YB-0158
CAS#: 1144043-83-3
Chemical Formula: C32H32N7Na2O7P
Exact Mass: 703.19
Molecular Weight: 703.600
Elemental Analysis: C, 54.63; H, 4.58; N, 13.94; Na, 6.53; O, 15.92; P, 4.40
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Synonym: YB-0158; YB0158; YB 0158; Wnt pathway inhibitor 2
IUPAC/Chemical Name: sodium 4-(((6S,9aS)-8-((1H-indazol-7-yl)methyl)-2-allyl-1-(benzylcarbamoyl)-4,7-dioxooctahydro-2H-pyrazino[2,1-c][1,2,4]triazin-6-yl)methyl)phenyl phosphate
InChi Key: BUCIVAHDHKFRLG-QLBXQKMFSA-L
InChi Code: InChI=1S/C32H34N7O7P.2Na/c1-2-15-37-21-29(40)38-27(16-22-11-13-26(14-12-22)46-47(43,44)45)31(41)36(19-25-10-6-9-24-18-34-35-30(24)25)20-28(38)39(37)32(42)33-17-23-7-4-3-5-8-23;;/h2-14,18,27-28H,1,15-17,19-21H2,(H,33,42)(H,34,35)(H2,43,44,45);;/q;2*+1/p-2/t27-,28-;;/m0../s1
SMILES Code: O=P([O-])([O-])OC1=CC=C(C[C@H](N2[C@@](CN3CC4=CC=CC5=C4NN=C5)([H])N(C(NCC6=CC=CC=C6)=O)N(CC=C)CC2=O)C3=O)C=C1.[Na+].[Na+]
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 703.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Masibag AN, Bergin CJ, Haebe JR, Zouggar A, Shah MS, Sandouka T, Mendes da Silva A, Desrochers FM, Fournier-Morin A, Benoit YD. Pharmacological targeting of Sam68 functions in colorectal cancer stem cells. iScience. 2021 Nov 14;24(12):103442. doi: 10.1016/j.isci.2021.103442. PMID: 34877499; PMCID: PMC8633986.