BSJ-04-146

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H123376

CAS#: N/A

Description: BSJ-04-146 is a FAK PROTAC.

Chemical Structure

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BSJ-04-146
CAS# N/A
Instruction

Theoretical Analysis

Hodoodo Cat#: H123376
Name: BSJ-04-146
CAS#: N/A
Chemical Formula: C50H59F3N8O8
Exact Mass: 956.44
Molecular Weight: 957.070
Elemental Analysis: C, 62.75; H, 6.21; F, 5.96; N, 11.71; O, 13.37

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: BSJ-04 146; BSJ 04-146; BSJ04146;

IUPAC/Chemical Name: 2-((2-((4-(1-(6-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3,4,5-tetrahydro-1H-isoindol-4-yl)oxy)acetamido)hexyl)piperidin-4-yl)-2-isopropoxy-5-methylphenyl)amino)-5-(trifluoromethyl)pyridin-4-yl)amino)-N-methylbenzamide

InChi Key: WVNSKJSUSUSRJV-UHFFFAOYSA-N

InChi Code: InChI=1S/C50H59F3N8O8/c1-29(2)69-41-25-34(30(3)24-38(41)58-42-26-37(35(27-56-42)50(51,52)53)57-36-14-8-7-12-32(36)46(64)54-4)31-18-22-60(23-19-31)21-10-6-5-9-20-55-44(63)28-68-40-15-11-13-33-45(40)49(67)61(48(33)66)39-16-17-43(62)59-47(39)65/h7-8,11-14,24-27,29,31,39-40H,5-6,9-10,15-23,28H2,1-4H3,(H,54,64)(H,55,63)(H2,56,57,58)(H,59,62,65)

SMILES Code: CNC(C1=CC=CC=C1NC2=CC(NC3=CC(C)=C(C4CCN(CCCCCCNC(COC5C(C(N(C6C(NC(CC6)=O)=O)C7=O)=O)=C7C=CC5)=O)CC4)C=C3OC(C)C)=NC=C2C(F)(F)F)=O

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 957.07 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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Koide E, Mohardt ML, Doctor ZM, Yang A, Hao M, Donovan KA, Kuismi CC, Nelson AJ, Abell K, Aguiar M, Che J, Stokes MP, Zhang T, Aguirre AJ, Fischer ES, Gray NS, Jiang B, Nabet B. Development and characterization of selective FAK inhibitors and PROTACs with in vivo activity. Chembiochem. 2023 Apr 23:e202300141. doi: 10.1002/cbic.202300141. Epub ahead of print. PMID: 37088717.