WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H525585
CAS#: 334970-65-9
Description: LY-402913 is a novel class of selective multidrug resistance protein (MRP1) inhibitor. reverses drug resistance to MRP1 substrates, such as doxorubicin, in HeLa-T5 cells (EC(50)=0.90 microM), while showing no inherent cytotoxicity. LY 402913 also shows selectivity ( approximately 22-fold) against the related transporter, P-glycoprotein, in HL60/Adr and HL60/Vinc cells. Finally, when dosed in combination with the oncolytic MRP1 substrate vincristine, LY 402913 delays the growth of MRP1-overexpressing tumors in vivo.
Hodoodo Cat#: H525585
Name: LY-402913
CAS#: 334970-65-9
Chemical Formula: C28H24ClN3O6
Exact Mass: 533.14
Molecular Weight: 533.970
Elemental Analysis: C, 62.98; H, 4.53; Cl, 6.64; N, 7.87; O, 17.98
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Synonym: LY-402913; LY 402913; LY402913.
IUPAC/Chemical Name: Benzeneacetamide, 3-(9-chloro-3-methyl-4-oxoisoxazolo(4,5-C)quinolin-5(4H)-yl)-N-(3,4,5-trimethoxyphenyl)-
InChi Key: VHYMJFJCXJXINF-UHFFFAOYSA-N
InChi Code: InChI=1S/C28H24ClN3O6/c1-15-24-27(38-31-15)25-19(29)9-6-10-20(25)32(28(24)34)18-8-5-7-16(11-18)12-23(33)30-17-13-21(35-2)26(37-4)22(14-17)36-3/h5-11,13-14H,12H2,1-4H3,(H,30,33)
SMILES Code: O=C(NC1=CC(OC)=C(OC)C(OC)=C1)CC2=CC=CC(N3C(C4=C(ON=C4C)C5=C3C=CC=C5Cl)=O)=C2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
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The following data is based on the product molecular weight 533.97 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Tawari NR, Bag S, Degani MS. Pharmacophore mapping of a series of
pyrrolopyrimidines, indolopyrimidines and their congeners as
multidrug-resistance-associated protein (MRP1) modulators. J Mol Model. 2008
Oct;14(10):911-21. doi: 10.1007/s00894-008-0330-z. Epub 2008 Jul 11. PubMed PMID:
18618153.
2: Norman BH, Gruber JM, Hollinshead SP, Wilson JW, Starling JJ, Law KL, Self TD,
Tabas LB, Williams DC, Paul DC, Wagner MM, Dantzig AH. Tricyclic isoxazoles are
novel inhibitors of the multidrug resistance protein (MRP1). Bioorg Med Chem
Lett. 2002 Mar 25;12(6):883-6. PubMed PMID: 11958985.
