ND-478

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Hodoodo CAT#: H130464

CAS#: N/A

Description: ND-478 is the prodrug of ND-322, which is a gelatinase inhibitor that is used to combat the damaging effects of neurological diseases caused by MMP-9. ND-322 is then further metabolized to form ND-364, which is an even more potent gelatinase inhibitor.

Chemical Structure

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ND-478
CAS# N/A
Instruction

Theoretical Analysis

Hodoodo Cat#: H130464
Name: ND-478
CAS#: N/A
Chemical Formula: C21H29Cl2N5O4S2
Exact Mass: 0.00
Molecular Weight: 550.510
Elemental Analysis: C, 45.82; H, 5.31; Cl, 12.88; N, 12.72; O, 11.62; S, 11.65

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: ND-478; ND478; ND 478

IUPAC/Chemical Name: (2S)-2-amino-5-guanidino-N-(4-(4-((thiiran-2-ylmethyl)sulfonyl)phenoxy)phenyl)pentanamide dihydrochloride

InChi Key: YYZCOYMRFSFGIR-KGSYHEICSA-N

InChi Code: InChI=1S/C21H27N5O4S2.2ClH/c22-19(2-1-11-25-21(23)24)20(27)26-14-3-5-15(6-4-14)30-16-7-9-18(10-8-16)32(28,29)13-17-12-31-17;;/h3-10,17,19H,1-2,11-13,22H2,(H,26,27)(H4,23,24,25);2*1H/t17?,19-;;/m0../s1

SMILES Code: NC(NCCC[C@@H](C(NC1=CC=C(C=C1)OC2=CC=C(C=C2)S(=O)(CC3SC3)=O)=O)N)=N.Cl.Cl

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 550.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Song W, Peng Z, Gooyit M, Suckow MA, Schroeder VA, Wolter WR, Lee M, Ikejiri M, Cui J, Gu Z, Chang M. Water-soluble mmp-9 inhibitor prodrug generates active metabolites that cross the blood-brain barrier. ACS Chem Neurosci. 2013 Aug 21;4(8):1168-73. doi: 10.1021/cn400077d. Epub 2013 May 30. PMID: 23687970; PMCID: PMC3750675.

2. Gooyit M, Lee M, Schroeder VA, Ikejiri M, Suckow MA, Mobashery S, Chang M. Selective water-soluble gelatinase inhibitor prodrugs. J Med Chem. 2011 Oct 13;54(19):6676-90. doi: 10.1021/jm200566e. Epub 2011 Sep 6. PMID: 21866961; PMCID: PMC3190643.