WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130466
CAS#: N/A
Description: OICR-8268 is a DCAF1 ligand, playing a key role in the future development of DCAF1 ligands for treating various cancers and further exploring the role/mechanism of DCAF1.
Hodoodo Cat#: H130466
Name: OICR-8268
CAS#: N/A
Chemical Formula: C19H14Cl2F2N4O2
Exact Mass: 438.05
Molecular Weight: 439.240
Elemental Analysis: C, 51.95; H, 3.21; Cl, 16.14; F, 8.65; N, 12.76; O, 7.28
This product is not in stock, which may be available by custom synthesis.
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Synonym: OICR-8268; OICR8268; OICR 8268
IUPAC/Chemical Name: (S)-N-(3-amino-1-(3-chloro-4-fluorophenyl)-3-oxopropyl)-3-(4-chloro-2-fluorophenyl)-1H-pyrazole-4-carboxamide
InChi Key: IPDMIUDPUBUHSU-INIZCTEOSA-N
InChi Code: InChI=1S/C19H14Cl2F2N4O2/c20-10-2-3-11(15(23)6-10)18-12(8-25-27-18)19(29)26-16(7-17(24)28)9-1-4-14(22)13(21)5-9/h1-6,8,16H,7H2,(H2,24,28)(H,25,27)(H,26,29)/t16-/m0/s1
SMILES Code: O=C(C1=CNN=C1C2=CC=C(Cl)C=C2F)N[C@H](C3=CC=C(F)C(Cl)=C3)CC(N)=O
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 439.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Li ASM, Kimani S, Wilson B, Noureldin M, González-Álvarez H, Mamai A, Hoffer L, Guilinger JP, Zhang Y, von Rechenberg M, Disch JS, Mulhern CJ, Slakman BL, Cuozzo JW, Dong A, Poda G, Mohammed M, Saraon P, Mittal M, Modh P, Rathod V, Patel B, Ackloo S, Santhakumar V, Szewczyk MM, Barsyte-Lovejoy D, Arrowsmith CH, Marcellus R, Guié MA, Keefe AD, Brown PJ, Halabelian L, Al-Awar R, Vedadi M. Discovery of Nanomolar DCAF1 Small Molecule Ligands. J Med Chem. 2023 Apr 13;66(7):5041-5060. doi: 10.1021/acs.jmedchem.2c02132. Epub 2023 Mar 22. PMID: 36948210; PMCID: PMC10108359.