WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130474
CAS#: N/A
Description: SE-1, also known as OSSL_051168, is an RhaS and RhaR (of the AraC family) protein inhibitor, in turn interfering with DNA binding and inhibiting VirF. SE-1 may prove to be useful as an antibacterial agent.
Hodoodo Cat#: H130474
Name: SE-1
CAS#: N/A
Chemical Formula: C23H23N3O2
Exact Mass: 373.18
Molecular Weight: 373.460
Elemental Analysis: C, 73.97; H, 6.21; N, 11.25; O, 8.57
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Synonym: SE-1; OSSL_051168; OSSL-051168; OSSL 051168
IUPAC/Chemical Name: 1'-butyl-4'-(nitromethyl)-1',4'-dihydro-2,3'-biquinoline
InChi Key: TWSGBFAOSUKOKN-UHFFFAOYSA-N
InChi Code: InChI=1S/C23H23N3O2/c1-2-3-14-25-15-20(22-13-12-17-8-4-6-10-21(17)24-22)19(16-26(27)28)18-9-5-7-11-23(18)25/h4-13,15,19H,2-3,14,16H2,1H3
SMILES Code: O=[N+](CC1C(C2=NC3=CC=CC=C3C=C2)=CN(CCCC)C4=C1C=CC=C4)[O-]
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 373.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Koppolu V, Osaka I, Skredenske JM, Kettle B, Hefty PS, Li J, Egan SM. Small-molecule inhibitor of the Shigella flexneri master virulence regulator VirF. Infect Immun. 2013 Nov;81(11):4220-31. doi: 10.1128/IAI.00919-13. Epub 2013 Sep 3. PMID: 24002059; PMCID: PMC3811841.
2. Skredenske JM, Koppolu V, Kolin A, Deng J, Kettle B, Taylor B, Egan SM. Identification of a small-molecule inhibitor of bacterial AraC family activators. J Biomol Screen. 2013 Jun;18(5):588-98. doi: 10.1177/1087057112474690. Epub 2013 Jan 30. PMID: 23364515; PMCID: PMC3663881.