STING agonist D61

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Hodoodo CAT#: H130470

CAS#: N/A

Description: STING agonist D61 is a stimulator of interferon gene (STING) agonist that has been found to increase the transcription of IFN-β and proinflammatory cytokine CXCL10. In a CT-26 syngeneic mice-bearing tumor model, STING agonist D61 was found to successfully suppress tumor activity.

Chemical Structure

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STING agonist D61
CAS# N/A
Instruction

Theoretical Analysis

Hodoodo Cat#: H130470
Name: STING agonist D61
CAS#: N/A
Chemical Formula: C29H29F3N8O4
Exact Mass: 610.23
Molecular Weight: 610.600
Elemental Analysis: C, 57.05; H, 4.79; F, 9.33; N, 18.35; O, 10.48

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: STING agonist D61

IUPAC/Chemical Name: 2-(1-ethyl-3-methyl-1H-pyrazole-5-carboxamido)-7-methoxy-1-(3-((5-(2-(trifluoromethyl)phenyl)oxazol-2-yl)amino)propyl)-1H-benzo[d]imidazole-5-carboxamide

InChi Key: SAIPDXPIJPBWOT-UHFFFAOYSA-N

InChi Code: InChI=1S/C29H29F3N8O4/c1-4-40-21(12-16(2)38-40)26(42)37-27-36-20-13-17(25(33)41)14-22(43-3)24(20)39(27)11-7-10-34-28-35-15-23(44-28)18-8-5-6-9-19(18)29(30,31)32/h5-6,8-9,12-15H,4,7,10-11H2,1-3H3,(H2,33,41)(H,34,35)(H,36,37,42)

SMILES Code: O=C(C1=CC(OC)=C2N(CCCNC3=NC=C(C4=CC=CC=C4C(F)(F)F)O3)C(NC(C5=CC(C)=NN5CC)=O)=NC2=C1)N

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 610.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Chen NN, Zhang H, Zhu QS, Zeng T, Dai W, Zhou YL, Xin GF, Wu BD, Gong SJ, Jiang ZY, You QD, Xu XL. Development of Orally Bioavailable Amidobenzimidazole Analogues Targeting Stimulator of Interferon Gene (STING) Receptor. J Med Chem. 2023 Apr 7. doi: 10.1021/acs.jmedchem.2c02046. Epub ahead of print. PMID: 37027512.