STOCK1N-37454

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Hodoodo CAT#: H130469

CAS#: N/A

Description: STOCK1N-37454 is an allosteric inhibitor of human serotonin transporter (hSERT) that is more potent than vilazodone and (S)-citalopram at binding to active pockets and expanding boundaries.

Chemical Structure

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STOCK1N-37454
CAS# N/A
Instruction

Theoretical Analysis

Hodoodo Cat#: H130469
Name: STOCK1N-37454
CAS#: N/A
Chemical Formula: C26H27N3O2
Exact Mass: 413.21
Molecular Weight: 413.520
Elemental Analysis: C, 75.52; H, 6.58; N, 10.16; O, 7.74

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: STOCK1N-37454; STOCK1N37454; STOCK1N 37454

IUPAC/Chemical Name: (1R,5S)-3-(3-(9H-carbazol-9-yl)-2-hydroxypropyl)-1,2,3,4,5,6-hexahydro-8H-1,5-methanopyrido[1,2-a][1,5]diazocin-8-one

InChi Key: GLQDHYZYYYRCEH-ABZYKWASSA-N

InChi Code: InChI=1S/C26H27N3O2/c30-20(17-28-24-8-3-1-6-21(24)22-7-2-4-9-25(22)28)16-27-13-18-12-19(15-27)23-10-5-11-26(31)29(23)14-18/h1-11,18-20,30H,12-17H2/t18-,19+,20?/m0/s1

SMILES Code: O=C1C=CC=C2N1C[C@]3([H])CN(CC(O)CN4C5=C(C6=C4C=CC=C6)C=CC=C5)C[C@@]2([H])C3

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 413.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Ayipo YO, Ahmad I, Chong CF, Zainurin NA, Najib SY, Patel H, Mordi MN. Carbazole derivatives as promising competitive and allosteric inhibitors of human serotonin transporter: computational pharmacology. J Biomol Struct Dyn. 2023 Apr 6:1-22. doi: 10.1080/07391102.2023.2198016. Epub ahead of print. PMID: 37021485.