WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130467
CAS#: N/A
Description: UT-11 is an inhibitor of mPGES-1. UT-11 was found to successfully suppress the production of PGE2 in human SK-N-AS cells and murine BV2 cells. UT-11 has demonstrated potential in treating neuroinflammatory conditions.
Hodoodo Cat#: H130467
Name: UT-11
CAS#: N/A
Chemical Formula: C17H19Cl2N3O2S
Exact Mass: 399.06
Molecular Weight: 400.318
Elemental Analysis: C, 51.01; H, 4.78; Cl, 17.71; N, 10.50; O, 7.99; S, 8.01
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Synonym: UT-11; UT11; UT 11
IUPAC/Chemical Name: (R)-1-(5,6-dichlorobenzo[d]thiazol-2-yl)-N-(tetrahydrofuran-3-yl)piperidine-4-carboxamide
InChi Key: CAIZZJVFQARMJL-LLVKDONJSA-N
InChi Code: InChI=1S/C17H19Cl2N3O2S/c18-12-7-14-15(8-13(12)19)25-17(21-14)22-4-1-10(2-5-22)16(23)20-11-3-6-24-9-11/h7-8,10-11H,1-6,9H2,(H,20,23)/t11-/m1/s1
SMILES Code: O=C(C1CCN(C2=NC3=CC(Cl)=C(Cl)C=C3S2)CC1)N[C@H]4COCC4
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 400.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Sluter MN, Bhuniya R, Yuan X, Ramaraju A, Chen Y, Yu Y, Parmar KR, Temrikar ZH, Srivastava A, Meibohm B, Jiang J, Yang CY. Novel, Brain-Permeable, Cross-Species Benzothiazole Inhibitors of Microsomal Prostaglandin E Synthase-1 (mPGES-1) Dampen Neuroinflammation In Vitro and In Vivo. ACS Pharmacol Transl Sci. 2023 Mar 21;6(4):587-599. doi: 10.1021/acsptsci.2c00241. PMID: 37082746; PMCID: PMC10111624.