WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H123418
CAS#: N/A
Description: TUG-2304 is a high potent FFA2 antagonist with IC50 values of 3−4 nM in both cAMP and GTPγS assays. TUG-2304 showed favorable physicochemical and pharmacokinetic properties, and the ability to completely inhibit propionateinduced neutrophil migration and respiratory burst.
Hodoodo Cat#: H123418
Name: TUG-2304
CAS#: N/A
Chemical Formula: C20H20F3N5O2
Exact Mass: 419.16
Molecular Weight: 419.410
Elemental Analysis: C, 57.28; H, 4.81; F, 13.59; N, 16.70; O, 7.63
This product is not in stock, which may be available by custom synthesis.
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Synonym: TUG-2304; TUG2304; TUG 2304
IUPAC/Chemical Name: (S)-N-(1-(1H-tetrazol-5-yl)-3-(4-(trifluoromethyl)phenyl)propan-2-yl)-2-(3-methoxyphenyl)acetamide
InChi Key: AFMDUVFVMUUFKZ-INIZCTEOSA-N
InChi Code: InChI=1S/C20H20F3N5O2/c1-30-17-4-2-3-14(10-17)11-19(29)24-16(12-18-25-27-28-26-18)9-13-5-7-15(8-6-13)20(21,22)23/h2-8,10,16H,9,11-12H2,1H3,(H,24,29)(H,25,26,27,28)/t16-/m0/s1
SMILES Code: O=C(N[C@@H](CC1=CC=C(C(F)(F)F)C=C1)CC2=NN=NN2)CC3=CC=CC(OC)=C3
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 419.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
Valentini A, Schultz-Knudsen K, Højgaard Hansen A, Tsakoumagkou A, Jenkins L, Christensen HB, Manandhar A, Milligan G, Ulven T, Rexen Ulven E. Discovery of Potent Tetrazole Free Fatty Acid Receptor 2 Antagonists. J Med Chem. 2023 May 2. doi: 10.1021/acs.jmedchem.2c01935. Epub ahead of print. PMID: 37129317.