WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H123465
CAS#: N/A
Description: AMC-109 is an antimicrobial peptide memetic.
Hodoodo Cat#: H123465
Name: AMC-109
CAS#: N/A
Chemical Formula: C43H69N11O3
Exact Mass: 787.56
Molecular Weight: 788.100
Elemental Analysis: C, 65.53; H, 8.83; N, 19.55; O, 6.09
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Synonym: AMC-109; AMC109; AMC 109;
IUPAC/Chemical Name: (S)-2-amino-5-guanidino-N-((S)-1-(((S)-5-guanidino-1-oxo-1-(phenethylamino)pentan-2-yl)amino)-1-oxo-3-(2,5,7-tri-tert-butyl-1H-indol-3-yl)propan-2-yl)pentanamide
InChi Key: ZVOYWSKEBVVLGW-ZDCRTTOTSA-N
InChi Code: InChI=1S/C43H69N11O3/c1-41(2,3)27-23-28-29(35(43(7,8)9)54-34(28)30(24-27)42(4,5)6)25-33(53-36(55)31(44)17-13-20-50-39(45)46)38(57)52-32(18-14-21-51-40(47)48)37(56)49-22-19-26-15-11-10-12-16-26/h10-12,15-16,23-24,31-33,54H,13-14,17-22,25,44H2,1-9H3,(H,49,56)(H,52,57)(H,53,55)(H4,45,46,50)(H4,47,48,51)/t31-,32-,33-/m0/s1
SMILES Code: O=C(N[C@H](C(NCCC1=CC=CC=C1)=O)CCCNC(N)=N)[C@@H](NC([C@@H](N)CCCNC(N)=N)=O)CC2=C(C(C)(C)C)NC3=C2C=C(C(C)(C)C)C=C3C(C)(C)C
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 788.10 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Laulund AS, Schwartz FA, Christophersen L, Høiby N, Svendsen JSM, Stensen W,
Thomsen K, Cavanagh JP, Moser C. Lactoferricin-inspired peptide AMC-109 augments
the effect of ciprofloxacin against Pseudomonas aeruginosa biofilm in chronic
murine wounds. J Glob Antimicrob Resist. 2022 Jun;29:185-193. doi:
10.1016/j.jgar.2021.12.015. Epub 2021 Dec 23. PMID: 34954415.
2: Håkansson J, Cavanagh JP, Stensen W, Mortensen B, Svendsen JS, Svenson J. In
vitro and in vivo antibacterial properties of peptide AMC-109 impregnated wound
dressings and gels. J Antibiot (Tokyo). 2021 May;74(5):337-345. doi:
10.1038/s41429-021-00406-5. Epub 2021 Jan 25. PMID: 33495549.