WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H123532
CAS#: N/A
Description: AM-A3 is a PROTAC targeting ER
Hodoodo Cat#: H123532
Name: AM-A3
CAS#: N/A
Chemical Formula: C58H61N5O9S2
Exact Mass: 1,035.39
Molecular Weight: 1,036.270
Elemental Analysis: C, 67.23; H, 5.93; N, 6.76; O, 13.90; S, 6.19
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Synonym: AMA-3; AM-A-3; AM-A3
IUPAC/Chemical Name: (2S,4R)-4-hydroxy-1-((S)-2-(5-(4-(2-(4-(6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophene-3-carbonyl)benzamido)ethyl)phenoxy)pentanamido)-3,3-dimethylbutanoyl)-N-((R)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide
InChi Key: VXEYUCNJDJXFGM-NOWQUMTASA-N
InChi Code: InChI=1S/C58H61N5O9S2/c1-34(37-11-15-39(16-12-37)52-35(2)60-33-73-52)61-56(70)47-30-44(66)32-63(47)57(71)54(58(3,4)5)62-49(67)8-6-7-29-72-45-24-9-36(10-25-45)27-28-59-55(69)41-17-13-38(14-18-41)51(68)50-46-26-23-43(65)31-48(46)74-53(50)40-19-21-42(64)22-20-40/h9-26,31,33-34,44,47,54,64-66H,6-8,27-30,32H2,1-5H3,(H,59,69)(H,61,70)(H,62,67)/t34-,44-,47+,54-/m1/s1
SMILES Code: OC1=CC=C(C2=C(C(C3=CC=C(C(NCCC4=CC=C(OCCCCC(N[C@@H](C(C)(C)C)C(N5[C@H](C(N[C@H](C)C6=CC=C(C7=C(C)N=CS7)C=C6)=O)C[C@@H](O)C5)=O)=O)C=C4)=O)C=C3)=O)C8=CC=C(O)C=C8S2)C=C1
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 1,036.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
Roberts BL, Ma ZX, Gao A, Leisten ED, Yin D, Xu W, Tang W. Two-Stage Strategy for Development of Proteolysis Targeting Chimeras and its Application for Estrogen Receptor Degraders. ACS Chem Biol. 2020 Jun 19;15(6):1487-1496. doi: 10.1021/acschembio.0c00140. Epub 2020 Apr 16. PMID: 32255606.