CPR3

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H123535

CAS#: N/A

Description: CPR3 is a PROTAC targeting IGF-1R and Src.

Chemical Structure

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CPR3
CAS# N/A
Instruction

Theoretical Analysis

Hodoodo Cat#: H123535
Name: CPR3
CAS#: N/A
Chemical Formula: C31H31N9O6
Exact Mass: 625.24
Molecular Weight: 625.650
Elemental Analysis: C, 59.51; H, 4.99; N, 20.15; O, 15.34

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: CPR3; CPR-3; CPR 3

IUPAC/Chemical Name: 2-(2,6-dioxopiperidin-3-yl)-4-((2-(2-(4-((4-((5-methyl-1H-pyrazol-3-yl)amino)pyrimidin-2-yl)amino)phenoxy)ethoxy)ethyl)amino)isoindoline-1,3-dione

InChi Key: YEBGDZYCAZJQHH-UHFFFAOYSA-N

InChi Code: InChI=1S/C31H31N9O6/c1-18-17-25(39-38-18)35-24-11-12-33-31(36-24)34-19-5-7-20(8-6-19)46-16-15-45-14-13-32-22-4-2-3-21-27(22)30(44)40(29(21)43)23-9-10-26(41)37-28(23)42/h2-8,11-12,17,23,32H,9-10,13-16H2,1H3,(H,37,41,42)(H3,33,34,35,36,38,39)

SMILES Code: CC1=CC(NC2=CC=NC(NC3=CC=C(OCCOCCNC4=CC=CC(C(N5C6CCC(NC6=O)=O)=O)=C4C5=O)C=C3)=N2)=NN1

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 625.65 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Shukla VK, Singh JS, Trivedi D, Hosur RV, Kumar A. NMR assignments of
mitochondrial cyclophilin Cpr3 from Saccharomyces cerevisiae. Biomol NMR Assign.
2016 Apr;10(1):203-6. doi: 10.1007/s12104-016-9667-x. Epub 2016 Feb 20. PMID:
26897529.

2: Koushi M, Asakai R. Bisindolylpyrrole Induces a Cpr3- and Porin1/2-Dependent
Transition in Yeast Mitochondrial Permeability in a Low Conductance State via
the AACs-Associated Pore. Int J Mol Sci. 2021 Jan 26;22(3):1212. doi:
10.3390/ijms22031212. PMID: 33530556; PMCID: PMC7865566.

3: Shukla VK, Singh JS, Vispute N, Ahmad B, Kumar A, Hosur RV. Unfolding of CPR3
Gets Initiated at the Active Site and Proceeds via Two Intermediates. Biophys J.
2017 Feb 28;112(4):605-619. doi: 10.1016/j.bpj.2016.12.020. PMID: 28256221;
PMCID: PMC5340121.

4: Tadema H, Kallenberg CG, Stegeman CA, Heeringa P. Reactivity against
complementary proteinase-3 is not increased in patients with PR3-ANCA-associated
vasculitis. PLoS One. 2011 Mar 17;6(3):e17972. doi:
10.1371/journal.pone.0017972. PMID: 21437233; PMCID: PMC3060099.

5: Yang J, Bautz DJ, Lionaki S, Hogan SL, Chin H, Tisch RM, Schmitz JL, Pressler
BM, Jennette JC, Falk RJ, Preston GA. ANCA patients have T cells responsive to
complementary PR-3 antigen. Kidney Int. 2008 Nov;74(9):1159-69. doi:
10.1038/ki.2008.309. Epub 2008 Jul 2. PMID: 18596726; PMCID: PMC2754720.

6: Kamei Y, Koushi M, Aoyama Y, Asakai R. The yeast mitochondrial permeability
transition is regulated by reactive oxygen species, endogenous Ca2+
and Cpr3, mediating cell death. Biochim Biophys Acta Bioenerg. 2018
Dec;1859(12):1313-1326. doi: 10.1016/j.bbabio.2018.07.004. Epub 2018 Jul 20.
PMID: 30031690.