WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H123536
CAS#: N/A
Description: CPR4 is a PROTAC targeting IGF-1R and Src.
Hodoodo Cat#: H123536
Name: CPR4
CAS#: N/A
Chemical Formula: C33H35N9O7
Exact Mass: 669.27
Molecular Weight: 669.700
Elemental Analysis: C, 59.19; H, 5.27; N, 18.82; O, 16.72
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.
Synonym: CPR4; CPR4; CPR4
IUPAC/Chemical Name: 2-(2,6-dioxopiperidin-3-yl)-4-((2-(2-(2-(4-((4-((5-methyl-1H-pyrazol-3-yl)amino)pyrimidin-2-yl)amino)phenoxy)ethoxy)ethoxy)ethyl)amino)isoindoline-1,3-dione
InChi Key: KSJXWXGDPRCSIV-UHFFFAOYSA-N
InChi Code: InChI=1S/C33H35N9O7/c1-20-19-27(41-40-20)37-26-11-12-35-33(38-26)36-21-5-7-22(8-6-21)49-18-17-48-16-15-47-14-13-34-24-4-2-3-23-29(24)32(46)42(31(23)45)25-9-10-28(43)39-30(25)44/h2-8,11-12,19,25,34H,9-10,13-18H2,1H3,(H,39,43,44)(H3,35,36,37,38,40,41)
SMILES Code: CC1=CC(NC2=CC=NC(NC3=CC=C(OCCOCCOCCNC4=CC=CC5=C4C(N(C5=O)C6C(NC(CC6)=O)=O)=O)C=C3)=N2)=NN1
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 669.70 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Choi HJ, Nguyen T, Park KS, Cha KC, Kim H, Lee KH, Hwang SO. Effect of
cardiopulmonary resuscitation on restoration of myocardial ATP in prolonged
ventricular fibrillation. Resuscitation. 2013 Jan;84(1):108-13. doi:
10.1016/j.resuscitation.2012.06.006. Epub 2012 Jun 19. PMID: 22727945.
2: Urano E, Shimizu S, Futahashi Y, Hamatake M, Morikawa Y, Takahashi N,
Fukazawa H, Yamamoto N, Komano J. Cyclin K/CPR4 inhibits primate lentiviral
replication by inactivating Tat/positive transcription elongation factor
b-dependent long terminal repeat transcription. AIDS. 2008 May 31;22(9):1081-3.
doi: 10.1097/QAD.0b013e3282fc7319. PMID: 18520353.
3: Jeltsch JM, Krozowski Z, Quirin-Stricker C, Gronemeyer H, Simpson RJ, Garnier
JM, Krust A, Jacob F, Chambon P. Cloning of the chicken progesterone receptor.
Proc Natl Acad Sci U S A. 1986 Aug;83(15):5424-8. doi: 10.1073/pnas.83.15.5424.
PMID: 2426697; PMCID: PMC386299.
4: Prariyachatigul C, Chaiprasert A, Meevootisom V, Pattanakitsakul S.
Assessment of a PCR technique for the detection and identification of
Cryptococcus neoformans. J Med Vet Mycol. 1996 Jul-Aug;34(4):251-8. doi:
10.1080/02681219680000431. PMID: 8873884.
5: Sirasoonthorn P, Kamiya K, Miura K. Antifungal roles of adult-specific
cuticular protein genes of the red flour beetle, Tribolium castaneum. J
Invertebr Pathol. 2021 Nov;186:107674. doi: 10.1016/j.jip.2021.107674. Epub 2021
Oct 1. PMID: 34606828.