WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H123537
CAS#: N/A
Description: KP-14 is a PROTAC targeting KRAS.
Hodoodo Cat#: H123537
Name: KP-14
CAS#: N/A
Chemical Formula: C41H41Cl3N6O8
Exact Mass: 850.21
Molecular Weight: 852.160
Elemental Analysis: C, 57.79; H, 4.85; Cl, 12.48; N, 9.86; O, 15.02
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Synonym: KP-14; KP14; KP 14
IUPAC/Chemical Name: (E)-N-(6-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)hexyl)-4-oxo-4-(4-(2',5',6-trichloro-4-methoxy-[1,1'-biphenyl]-3-carbonyl)piperazin-1-yl)but-2-enamide
InChi Key: LPVAFJZSEOPFFT-BUHFOSPRSA-N
InChi Code: InChI=1S/C41H41Cl3N6O8/c1-58-33-23-30(44)27(26-21-24(42)9-10-29(26)43)22-28(33)39(55)49-19-17-48(18-20-49)36(53)14-13-34(51)46-16-5-3-2-4-15-45-31-8-6-7-25-37(31)41(57)50(40(25)56)32-11-12-35(52)47-38(32)54/h6-10,13-14,21-23,32,45H,2-5,11-12,15-20H2,1H3,(H,46,51)(H,47,52,54)/b14-13+
SMILES Code: O=C(CCC1N(C2=O)C(C3=C2C=CC=C3NCCCCCCNC(/C=C/C(N4CCN(C(C5=C(OC)C=C(Cl)C(C6=CC(Cl)=CC=C6Cl)=C5)=O)CC4)=O)=O)=O)NC1=O
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 852.16 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Pranaw K, Pidlisnyuk V, Trögl J, Malinská H. Bioprospecting of a Novel Plant
Growth-Promoting Bacterium Bacillus Altitudinis KP-14 for Enhancing
Miscanthus × giganteus Growth in Metals Contaminated Soil. Biology
(Basel). 2020 Sep 22;9(9):305. doi: 10.3390/biology9090305. PMID: 32972004;
PMCID: PMC7564662.
2: Makri A, Pissimissis N, Lembessis P, Polychronakos C, Koutsilieris M. The
kisspeptin (KiSS-1)/GPR54 system in cancer biology. Cancer Treat Rev. 2008
Dec;34(8):682-92. doi: 10.1016/j.ctrv.2008.05.007. Epub 2008 Jun 25. PMID:
18583061.
3: Prabhu VV, Sakthivel KM, Guruvayoorappan C. Kisspeptins (KiSS-1): essential
players in suppressing tumor metastasis. Asian Pac J Cancer Prev.
2013;14(11):6215-20. doi: 10.7314/apjcp.2013.14.11.6215. PMID: 24377507.
4: Kirby HR, Maguire JJ, Colledge WH, Davenport AP. International Union of Basic
and Clinical Pharmacology. LXXVII. Kisspeptin receptor nomenclature,
distribution, and function. Pharmacol Rev. 2010 Dec;62(4):565-78. doi:
10.1124/pr.110.002774. PMID: 21079036; PMCID: PMC2993257.
5: Lee CH, Chang CC, Liu JW, Chen RF, Yang KD. Sialic acid involved in
hypermucoviscosity phenotype of Klebsiella pneumoniae and associated with
resistance to neutrophil phagocytosis. Virulence. 2014 Aug 15;5(6):673-9. doi:
10.4161/viru.32076. Epub 2014 Aug 5. PMID: 25098744; PMCID: PMC4139408.
