NR-6A

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H123538

CAS#: N/A

Description: NR-6A is a PROTAC targeting p38.

Chemical Structure

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NR-6A
CAS# N/A
Instruction

Theoretical Analysis

Hodoodo Cat#: H123538
Name: NR-6A
CAS#: N/A
Chemical Formula: C50H55BrF2N8O7
Exact Mass: 996.33
Molecular Weight: 997.940
Elemental Analysis: C, 60.18; H, 5.56; Br, 8.01; F, 3.81; N, 11.23; O, 11.22

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: NR-6A; NR6A; NR 6A

IUPAC/Chemical Name: 3-(3-bromo-4-((2,4-difluorobenzyl)oxy)-6-methyl-2-oxopyridin-1(2H)-yl)-N-(4-(1-(4-((6-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)hexyl)amino)-4-oxobutyl)-1H-1,2,3-triazol-4-yl)butyl)-4-methylbenzamide

InChi Key: DYERNVOWSSIIQF-UHFFFAOYSA-N

InChi Code: InChI=1S/C50H55BrF2N8O7/c1-31-16-17-34(26-42(31)61-32(2)25-43(46(51)50(61)67)68-30-35-18-19-36(52)27-40(35)53)47(64)55-23-8-6-13-37-28-59(58-57-37)24-10-15-44(62)54-22-7-4-3-5-11-33-12-9-14-38-39(33)29-60(49(38)66)41-20-21-45(63)56-48(41)65/h9,12,14,16-19,25-28,41H,3-8,10-11,13,15,20-24,29-30H2,1-2H3,(H,54,62)(H,55,64)(H,56,63,65)

SMILES Code: FC1=CC=C(COC(C=C(C)N2C3=CC(C(NCCCCC4=CN(CCCC(NCCCCCCC5=C(CN(C6C(NC(CC6)=O)=O)C7=O)C7=CC=C5)=O)N=N4)=O)=CC=C3C)=C(Br)C2=O)C(F)=C1

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 997.94 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Harrell LJ, Mirrett S, Reller LB. Subcultures of BACTEC-positive but gram or
acridine orange stain-negative NR 6A and 7A blood culture bottles are
unnecessary. Diagn Microbiol Infect Dis. 1994 Nov;20(3):121-5. doi:
10.1016/0732-8893(94)90105-8. PMID: 7874878.

2: Courcol RJ, Durocher AV, Roussel-Delvallez M, Fruchart A, Martin GR. Routine
evaluation of BACTEC NR-16A and NR-17A media. J Clin Microbiol. 1988
Sep;26(9):1619-22. doi: 10.1128/jcm.26.9.1619-1622.1988. PMID: 3183014; PMCID:
PMC266682.

3: Forward KR, Kerr E, Dalton M. An assessment of the anaerobic vial of paired
NR 6A and NR 7N Bactec blood cultures. Can J Infect Dis. 1994 Jan;5(1):37-40.
doi: 10.1155/1994/612515. PMID: 22346480; PMCID: PMC3250841.

4: Morello JA, Matushek SM, Dunne WM, Hinds DB. Performance of a BACTEC
nonradiometric medium for pediatric blood cultures. J Clin Microbiol. 1991
Feb;29(2):359-62. doi: 10.1128/jcm.29.2.359-362.1991. PMID: 2007644; PMCID:
PMC269767.

5: Kern W, Kirchner S, Vanek E. Resin versus standard blood culture media used
with the new BACTEC automated infrared system: an evaluation in febrile
granulocytopenic patients. Zentralbl Bakteriol. 1990 Jun;273(2):156-63. doi:
10.1016/s0934-8840(11)80243-4. PMID: 2400531.