WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H123548
CAS#: N/A
Description: YZ-268 is a PROTAC targeting HDAC.
Hodoodo Cat#: H123548
Name: YZ-268
CAS#: N/A
Chemical Formula: C49H57N9O7
Exact Mass: 883.44
Molecular Weight: 884.050
Elemental Analysis: C, 66.57; H, 6.50; N, 14.26; O, 12.67
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Synonym: YZ-268; YZ268; YZ 268
IUPAC/Chemical Name: 4-((1-butyl-3-(4-((7-(4-(((4-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)benzyl)amino)methyl)-1H-1,2,3-triazol-1-yl)heptyl)oxy)phenyl)ureido)methyl)-N-hydroxybenzamide
InChi Key: WFLGLHJDVMTEJN-UHFFFAOYSA-N
InChi Code: InChI=1S/C49H57N9O7/c1-2-3-26-56(31-35-14-18-37(19-15-35)46(60)54-64)49(63)51-38-20-22-40(23-21-38)65-28-8-6-4-5-7-27-57-32-39(53-55-57)30-50-29-34-12-16-36(17-13-34)41-10-9-11-42-43(41)33-58(48(42)62)44-24-25-45(59)52-47(44)61/h9-23,32,44,50,64H,2-8,24-31,33H2,1H3,(H,51,63)(H,54,60)(H,52,59,61)
SMILES Code: O=C(NC1=O)CCC1N(C2=O)CC3=C2C=CC=C3C4=CC=C(CNCC5=CN(CCCCCCCOC6=CC=C(NC(N(CCCC)CC7=CC=C(C(NO)=O)C=C7)=O)C=C6)N=N5)C=C4
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 884.05 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
He M, Cao C, Ni Z, Liu Y, Song P, Hao S, He Y, Sun X, Rao Y. PROTACs: great opportunities for academia and industry (an update from 2020 to 2021). Signal Transduct Target Ther. 2022 Jun 9;7(1):181. doi: 10.1038/s41392-022-00999-9. PMID: 35680848; PMCID: PMC9178337.