WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H123559
CAS#: N/A
Description: CU-72 is a TLR inhibitor
Hodoodo Cat#: H123559
Name: CU-72
CAS#: N/A
Chemical Formula: C26H14ClF7N2O2
Exact Mass: 554.06
Molecular Weight: 554.850
Elemental Analysis: C, 56.28; H, 2.54; Cl, 6.39; F, 23.97; N, 5.05; O, 5.77
This product is not in stock, which may be available by custom synthesis.
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Synonym: CU-72; CU72; CU 72
IUPAC/Chemical Name: 2-chloro-6-fluoro-N-(4-(3-(trifluoromethyl)-5-(5-(trifluoromethyl)pyridin-3-yl)phenoxy)phenyl)benzamide
InChi Key: DUELSTAKQKXGOV-UHFFFAOYSA-N
InChi Code: InChI=1S/C26H14ClF7N2O2/c27-21-2-1-3-22(28)23(21)24(37)36-18-4-6-19(7-5-18)38-20-10-14(8-16(11-20)25(29,30)31)15-9-17(13-35-12-15)26(32,33)34/h1-13H,(H,36,37)
SMILES Code: ClC(C=CC=C1F)=C1C(NC2=CC=C(C=C2)OC3=CC(C(F)(F)F)=CC(C4=CN=CC(C(F)(F)F)=C4)=C3)=O
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 554.85 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
Padilla-Salinas R, Anderson R, Sakaniwa K, Zhang S, Nordeen P, Lu C, Shimizu T, Yin H. Discovery of Novel Small Molecule Dual Inhibitors Targeting Toll-Like Receptors 7 and 8. J Med Chem. 2019 Nov 27;62(22):10221-10244. doi: 10.1021/acs.jmedchem.9b01201. Epub 2019 Nov 18. PMID: 31687820.