WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H123555
CAS#: N/A
Description: SPB5208 is a PROTAC targeting BTK.
Hodoodo Cat#: H123555
Name: SPB5208
CAS#: N/A
Chemical Formula: C44H47N7O9
Exact Mass: 817.34
Molecular Weight: 817.900
Elemental Analysis: C, 64.61; H, 5.79; N, 11.99; O, 17.60
This product is not in stock, which may be available by custom synthesis.
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Synonym: SPB5208; SPB 5208; SPB-5208
IUPAC/Chemical Name: 4-(2-(2-(2-(2-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)piperidin-1-yl)ethoxy)ethoxy)ethoxy)ethoxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
InChi Key: PCALLPMCBXZHIT-UHFFFAOYSA-N
InChi Code: InChI=1S/C44H47N7O9/c45-34-17-18-46-41-39(34)40(29-11-13-32(14-12-29)60-31-7-2-1-3-8-31)48-51(41)30-6-5-19-49(28-30)20-21-56-22-23-57-24-25-58-26-27-59-36-10-4-9-33-38(36)44(55)50(43(33)54)35-15-16-37(52)47-42(35)53/h1-4,7-14,17-18,30,35H,5-6,15-16,19-28H2,(H2,45,46)(H,47,52,53)
SMILES Code: O=C1NC(C(CC1)N2C(C3=C(C2=O)C(OCCOCCOCCOCCN4CCCC(N5N=C(C6=CC=C(OC7=CC=CC=C7)C=C6)C8=C5N=CC=C8N)C4)=CC=C3)=O)=O
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 817.90 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1.Yu F, Cai M, Shao L, Zhang J. Targeting Protein Kinases Degradation by PROTACs. Front Chem. 2021 Jun 30;9:679120. doi: 10.3389/fchem.2021.679120. PMID: 34277564; PMCID: PMC8279777.
2. He M, Cao C, Ni Z, Liu Y, Song P, Hao S, He Y, Sun X, Rao Y. PROTACs: great opportunities for academia and industry (an update from 2020 to 2021). Signal Transduct Target Ther. 2022 Jun 9;7(1):181. doi: 10.1038/s41392-022-00999-9. PMID: 35680848; PMCID: PMC9178337.