YX-2-107
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Hodoodo CAT#: H123553

CAS#: 2417408-46-7

Description: YX-2-107 is a PROTAC targeting CDK2/4/6.

Chemical Structure

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YX-2-107
CAS# 2417408-46-7
Instruction

Theoretical Analysis

Hodoodo Cat#: H123553
Name: YX-2-107
CAS#: 2417408-46-7
Chemical Formula: C45H51N11O9
Exact Mass: 889.39
Molecular Weight: 889.970
Elemental Analysis: C, 60.73; H, 5.78; N, 17.31; O, 16.18

Price and Availability

Size Price Availability Quantity
5mg USD 950 2 Weeks
10mg USD 1650 2 Weeks
200mg USD 3650 2 Weeks
500mg USD 5650 2 Weeks
1g USD 8650 2 Weeks
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Synonym: YX-2-107; SCHEMBL24172331; HY-148530; CS-0634381

IUPAC/Chemical Name: N-(4-((2-(4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)-2-oxoethyl)amino)butyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide

InChi Key: JNYCZFGLJGFFEL-UHFFFAOYSA-N

InChi Code: InChI=1S/C45H51N11O9/c1-26-31-23-49-45(52-40(31)55(28-8-3-4-9-28)43(63)38(26)27(2)57)50-34-14-12-29(22-48-34)53-18-20-54(21-19-53)37(60)24-46-16-5-6-17-47-36(59)25-65-33-11-7-10-30-39(33)44(64)56(42(30)62)32-13-15-35(58)51-41(32)61/h7,10-12,14,22-23,28,32,46H,3-6,8-9,13,15-21,24-25H2,1-2H3,(H,47,59)(H,51,58,61)(H,48,49,50,52)

SMILES Code: O=C1NC(C(CC1)N2C(C3=C(C2=O)C(OCC(NCCCCNCC(N4CCN(CC4)C5=CN=C(NC6=NC(N(C7CCCC7)C(C(C(C)=O)=C8C)=O)=C8C=N6)C=C5)=O)=O)=CC=C3)=O)=O

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 889.97 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Porazzi P, De Dominici M, Salvino J, Calabretta B. Targeting the CDK6
Dependence of Ph+ Acute Lymphoblastic Leukemia. Genes (Basel). 2021 Aug
29;12(9):1355. doi: 10.3390/genes12091355. PMID: 34573335; PMCID: PMC8467343.

2: De Dominici M, Porazzi P, Xiao Y, Chao A, Tang HY, Kumar G, Fortina P,
Spinelli O, Rambaldi A, Peterson LF, Petruk S, Barletta C, Mazo A, Cingolani G,
Salvino JM, Calabretta B. Selective inhibition of Ph-positive ALL cell growth
through kinase-dependent and -independent effects by CDK6-specific PROTACs.
Blood. 2020 Apr 30;135(18):1560-1573. doi: 10.1182/blood.2019003604. PMID:
32040545; PMCID: PMC7193186.