ST-1803

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H123602

CAS#: N/A

Description: ST-1803 is a SphK inhibitor with IC50 values: 7.3 μM (SphK1), 6.5 μM (SphK2). ST-1802 is a promising candidate for further in vivo investigations and structural development.

Chemical Structure

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ST-1803
CAS# N/A
Instruction

Theoretical Analysis

Hodoodo Cat#: H123602
Name: ST-1803
CAS#: N/A
Chemical Formula: C10H8N4S3
Exact Mass: 279.99
Molecular Weight: 280.380
Elemental Analysis: C, 42.84; H, 2.88; N, 19.98; S, 34.30

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: ST-1803; ST 1803; ST1803

IUPAC/Chemical Name: N-(4-methylthiazol-2-yl)-[2,4'-bithiazol]-2'-amine

InChi Key: MTDICDDISWICOM-UHFFFAOYSA-N

InChi Code: InChI=1S/C10H8N4S3/c1-6-4-16-9(12-6)14-10-13-7(5-17-10)8-11-2-3-15-8/h2-5H,1H3,(H,12,13,14)

SMILES Code: CC1=CSC(NC2=NC(C3=NC=CS3)=CS2)=N1

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 280.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Vogt D, Weber J, Ihlefeld K, Brüggerhoff A, Proschak E, Stark H. Design,
synthesis and evaluation of 2-aminothiazole derivatives as sphingosine kinase
inhibitors. Bioorg Med Chem. 2014 Oct 1;22(19):5354-67. doi:
10.1016/j.bmc.2014.07.044. Epub 2014 Aug 6. PMID: 25150091.

2: Vitovskaia GA, Anan'eva EP, Grinberg TA, Buklova VN, Kozlov AI. Vliianie
istochnikov ugleroda i azota na sintez ékzopolisakharida Cryptococcus laurentii
[Effect of carbon and nitrogen sources on exopolysaccharide synthesis by
Cryptococcus laurentii]. Prikl Biokhim Mikrobiol. 1983 Nov-Dec;19(6):728-32.
Russian. PMID: 6664960.