WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H123645
CAS#: N/A
Description: JH-530 Is a potent Methuosis Inducer for the Treatment of Triple-Negative Breast Cancer. JH530 showed excellent anti-proliferative activities and vacuolization capacity in TNBC. The mechanism research indicated that JH530 caused cell death through inducing methuosis of cancer cells. Furthermore, JH530 inhibited tumor growth remarkably in the HCC1806 xenograft model without an apparent decrease in body weight.
Hodoodo Cat#: H123645
Name: JH530
CAS#: N/A
Chemical Formula: C22H24BrN7O2S
Exact Mass: 529.09
Molecular Weight: 530.450
Elemental Analysis: C, 49.82; H, 4.56; Br, 15.06; N, 18.48; O, 6.03; S, 6.04
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Synonym: JH530; JH-530; JH 530
IUPAC/Chemical Name: 6-bromo-N-(2-methoxy-4-((5-(methylthio)-2-(piperazin-1-yl)pyrimidin-4-yl)amino)phenyl)picolinamide
InChi Key: ZMAGFFCQJPNJDK-UHFFFAOYSA-N
InChi Code: InChI=1S/C22H24BrN7O2S/c1-32-17-12-14(6-7-15(17)28-21(31)16-4-3-5-19(23)27-16)26-20-18(33-2)13-25-22(29-20)30-10-8-24-9-11-30/h3-7,12-13,24H,8-11H2,1-2H3,(H,28,31)(H,25,26,29)
SMILES Code: BrC1=NC(C(NC2=C(OC)C=C(NC3=NC(N4CCNCC4)=NC=C3SC)C=C2)=O)=CC=C1
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 530.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
He J, Wang L, Mi D, Guan T, Liu W, He P, Gu H, Li Y, Peng Y, Jia AQ, Chen C, Chen Y. Discovery of Pyrimidinediamine Derivatives as Potent Methuosis Inducers for the Treatment of Triple-Negative Breast Cancer. J Med Chem. 2023 May 22. doi: 10.1021/acs.jmedchem.3c00090. Epub ahead of print. PMID: 37212861.