WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H123651
CAS#: N/A
Description: PTD10 is a highly potent BTK degrader (DC50 0.5 nM) that inhibited cell growth and induced apoptosis at lower concentrations than the two parent molecules, as well as three previously reported BTK PROTACs, and had improved selectivity compared to ibrutinib-based BTK PROTACs.
Hodoodo Cat#: H123651
Name: PTD10
CAS#: N/A
Chemical Formula: C49H51N11O8
Exact Mass: 921.39
Molecular Weight: 922.020
Elemental Analysis: C, 63.83; H, 5.58; N, 16.71; O, 13.88
This product is not in stock, which may be available by custom synthesis.
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Synonym: PTD10; PTD-10; PTD 10
IUPAC/Chemical Name: 4-((2-((S)-4-(6-((2'-(7,7-dimethyl-1-oxo-1,3,4,6,7,8-hexahydro-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-2-yl)-3'-(hydroxymethyl)-1-methyl-6-oxo-1,6-dihydro-[3,4'-bipyridin]-5-yl)amino)pyridin-3-yl)-3-methylpiperazin-1-yl)-2-oxoethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
InChi Key: DGDYTCIJBXSVPQ-XLYAUNJQSA-N
InChi Code: InChI=1S/C49H51N11O8/c1-27-24-56(41(63)23-51-34-7-5-6-32-42(34)48(68)60(45(32)65)36-9-11-40(62)54-44(36)64)14-15-57(27)30-8-10-39(52-22-30)53-35-18-29(25-55(4)46(35)66)31-12-13-50-43(33(31)26-61)59-17-16-58-37(47(59)67)19-28-20-49(2,3)21-38(28)58/h5-8,10,12-13,18-19,22,25,27,36,51,61H,9,11,14-17,20-21,23-24,26H2,1-4H3,(H,52,53)(H,54,62,64)/t27-,36?/m0/s1
SMILES Code: OCC1=C(N2CCN3C(C2=O)=CC4=C3CC(C)(C)C4)N=CC=C1C5=CN(C)C(C(NC6=NC=C(N7[C@@H](C)CN(C(CNC8=C(C(N(C9CCC(NC9=O)=O)C%10=O)=O)C%10=CC=C8)=O)CC7)C=C6)=C5)=O
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 922.02 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Li YQ, Lannigan WG, Davoodi S, Daryaee F, Corrionero A, Alfonso P, Rodriguez-
Santamaria JA, Wang N, Haley JD, Tonge PJ. Discovery of Novel Bruton's Tyrosine
Kinase PROTACs with Enhanced Selectivity and Cellular Efficacy. J Med Chem. 2023
May 17. doi: 10.1021/acs.jmedchem.3c00176. Epub ahead of print. PMID: 37195170.
2: Vlasova AN, Paim FC, Kandasamy S, Alhamo MA, Fischer DD, Langel SN, Deblais
L, Kumar A, Chepngeno J, Shao L, Huang HC, Candelero-Rueda RA, Rajashekara G,
Saif LJ. Protein Malnutrition Modifies Innate Immunity and Gene Expression by
Intestinal Epithelial Cells and Human Rotavirus Infection in Neonatal
Gnotobiotic Pigs. mSphere. 2017 Mar 1;2(2):e00046-17. doi:
10.1128/mSphere.00046-17. PMID: 28261667; PMCID: PMC5332602.
