EGFRL858R/T790M inhibitor 28f

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Hodoodo CAT#: H130490

CAS#: TBD

Description: EGFRL858R/T790M inhibitor 28f is a selective EGFR L858R/T790M inhibitor, exhibiting strong inhibitory activity against EGFR L858R/T790M (IC50 = 3.5 nM) and greater than 368-fold selectivity over EGFR WT (IC50 = 1290 nM), a 6.7-fold improvement over osimertinib, effectively inhibiting downstream signaling pathways and inducing apoptosis in mutant cells.

Chemical Structure

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EGFRL858R/T790M inhibitor 28f
CAS# TBD
Instruction

Theoretical Analysis

Hodoodo Cat#: H130490
Name: EGFRL858R/T790M inhibitor 28f
CAS#: TBD
Chemical Formula: C28H28FN7O
Exact Mass: 497.23
Molecular Weight: 497.578
Elemental Analysis: C, 67.59; H, 5.67; F, 3.82; N, 19.71; O, 3.22

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: EGFRL858R/ T790M inhibitor 28f, EGFRL858R / T790M inhibitor 28f, EGFRL858R/T790M-28f, EGFRL858R/T790M 28f

IUPAC/Chemical Name: N-(3-((6-Fluoro-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)quinazolin-4-yl)amino)phenyl)acrylamide

InChi Key: KDWNVZXLHSMELQ-UHFFFAOYSA-N

InChi Code: InChI=1S/C28H28FN7O/c1-3-26(37)30-21-5-4-6-22(18-21)31-27-24-17-19(29)7-12-25(24)33-28(34-27)32-20-8-10-23(11-9-20)36-15-13-35(2)14-16-36/h3-12,17-18H,1,13-16H2,2H3,(H,30,37)(H2,31,32,33,34)

SMILES Code: C=CC(NC1=CC=CC(NC2=C3C=C(F)C=CC3=NC(NC4=CC=C(N5CCN(C)CC5)C=C4)=N2)=C1)=O

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 497.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Pei J, Wang G, Wang A, Wu C, Pan X, Shuai W, Bu F, Zhu Y, Wang Y, Ouyang L, Li W. Design, Synthesis, and Antitumor Activity of Potent and Selective EGFR L858R/T790M Inhibitors and Identification of a Combination Therapy to Overcome Acquired Resistance in Models of Non-small-cell Lung Cancer. J Med Chem. 2023 Apr 27;66(8):5719-5752. doi: 10.1021/acs.jmedchem.3c00027. Epub 2023 Apr 12. PMID: 37042119.