WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130476
CAS#: Unknown
Description: EIDD-036 prodrug 13L is a novel pH-responsive water-soluble prodrug of EIDD-036. EIDD-036, also known as EPRX-036, as well as progesterone 20-oxime (P4-20-O) or 20-(hydroxyimino)pregn-4-en-3-one, is a synthetic, water-soluble analogue of progesterone, a neurosteroid, and the active metabolite of EIDD-1723 (EPRX-01723), a medication developed for the potential treatment of traumatic brain injury.
Hodoodo Cat#: H130476
Name: EIDD-036 prodrug 13L
CAS#: Unknown
Chemical Formula: C28H43N3O3
Exact Mass: 469.33
Molecular Weight: 469.670
Elemental Analysis: C, 71.61; H, 9.23; N, 8.95; O, 10.22
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Synonym: EIDD-036 prodrug 13; EPRX-036 prodrug;
IUPAC/Chemical Name: (8S,9S,10R,13S,14S,17S)-10,13-Dimethyl-17-((E)-1-(((methyl(((S)-pyrrolidin-2-yl)methyl)carbamoyl)oxy)imino)ethyl)-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3H-cyclopenta[a]phenanthren-3-one
InChi Key: PDMWELPRTMPQBR-NOIOUIOGSA-N
InChi Code: InChI=1S/C28H43N3O3/c1-18(30-34-26(33)31(4)17-20-6-5-15-29-20)23-9-10-24-22-8-7-19-16-21(32)11-13-27(19,2)25(22)12-14-28(23,24)3/h16,20,22-25,29H,5-15,17H2,1-4H3/b30-18+/t20-,22-,23+,24-,25-,27-,28+/m0/s1
SMILES Code: O=C1CC[C@]2(C)[C@@]3([H])CC[C@]4(C)[C@@H](/C(C)=N/OC(N(C)C[C@H]5NCCC5)=O)CC[C@@]4([H])[C@]3([H])CCC2=C1
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 469.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
Fritzemeier RG, van der Westhuyzen AE, D'Erasmo M, Sharma SK, Bartsch P, Hodson LE, Liu K, Wali B, Sayeed I, Liotta DC. Neurotherapeutic Potential of Water-Soluble pH-Responsive Prodrugs of EIDD-036 in Traumatic Brain Injury. J Med Chem. 2023 Apr 27;66(8):5397-5414. doi: 10.1021/acs.jmedchem.2c01484. Epub 2023 Apr 7. PMID: 37026870.
