GNS-1481

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H130486

CAS#: 1903008-81-0

Description: GNS-1481 is a novel EGFR kinase inhibitor, selectively targeting T790M mutant isoforms of EGFR.

Chemical Structure

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GNS-1481
CAS# 1903008-81-0
Instruction

Theoretical Analysis

Hodoodo Cat#: H130486
Name: GNS-1481
CAS#: 1903008-81-0
Chemical Formula: C27H34N8O3
Exact Mass: 518.28
Molecular Weight: 518.622
Elemental Analysis: C, 62.53; H, 6.61; N, 21.61; O, 9.25

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: GNS1481, GNS 1481, GNS - 1481

IUPAC/Chemical Name: N-{5-[4-(3-Cyclopropyl-4-dimethylaminomethyl-pyrazol-1-yl)-pyrimidin-2-ylamino]-4-methoxy-2-morpholin-4-yl-phenyl}-acrylamide

InChi Key: SEKXPOMGSBSXQJ-UHFFFAOYSA-N

InChi Code: InChI=1S/C27H34N8O3/c1-5-25(36)29-20-14-21(23(37-4)15-22(20)34-10-12-38-13-11-34)30-27-28-9-8-24(31-27)35-17-19(16-33(2)3)26(32-35)18-6-7-18/h5,8-9,14-15,17-18H,1,6-7,10-13,16H2,2-4H3,(H,29,36)(H,28,30,31)

SMILES Code: C=CC(NC1=CC(NC2=NC=CC(N3C=C(CN(C)C)C(C4CC4)=N3)=N2)=C(OC)C=C1N5CCOCC5)=O

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 518.62 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Rho JK, Lee IY, Choi YJ, Choi CM, Hur JY, Koh JS, Lee J, Suh BC, Song HJ, Salgaonkar P, Lee J, Lee J, Jung DS, Kim SY, Woo DC, Baek IJ, Lee JY, Ha CH, Sung YH, Kim JK, Kim WS, Song JS, Kim CH, Bivona TG, Lee JC. Superior Efficacy and Selectivity of Novel Small-Molecule Kinase Inhibitors of T790M-Mutant EGFR in Preclinical Models of Lung Cancer. Cancer Res. 2017 Mar 1;77(5):1200-1211. doi: 10.1158/0008-5472.CAN-16-2432. Epub 2017 Jan 12. PMID: 28082405; PMCID: PMC5334209.