WDR5 Inhibitor 262

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Hodoodo CAT#: H130492

CAS#: WDR5 Inhibitor 262

Description: WDR5 Inhibitor 262 is a highly potent WDR5 inhibitor.

Chemical Structure

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WDR5 Inhibitor 262
CAS# WDR5 Inhibitor 262
Instruction

Theoretical Analysis

Hodoodo Cat#: H130492
Name: WDR5 Inhibitor 262
CAS#: WDR5 Inhibitor 262
Chemical Formula: C29H31N7O2
Exact Mass: 509.25
Molecular Weight: 509.610
Elemental Analysis: C, 68.35; H, 6.13; N, 19.24; O, 6.28

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: WDR5 Inhibitor-262, WDR5 262, WDR5-262

IUPAC/Chemical Name: (S)-6-(1-(5-(1,3-Dimethyl-1H-pyrazol-4-yl)-7-((2-methyl-1H-imidazol-1-yl)methyl)-1-oxo-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)-4-ethoxynicotinonitrile

InChi Key: NRVDCMIJTOZKGP-IBGZPJMESA-N

InChi Code: InChI=1S/C29H31N7O2/c1-6-38-28-13-27(32-15-22(28)14-30)19(3)36-9-7-23-24(26-17-34(5)33-18(26)2)11-21(12-25(23)29(36)37)16-35-10-8-31-20(35)4/h8,10-13,15,17,19H,6-7,9,16H2,1-5H3/t19-/m0/s1

SMILES Code: N#CC1=CN=C([C@@H](N(CCC2=C3C=C(CN4C=CN=C4C)C=C2C5=CN(C)N=C5C)C3=O)C)C=C1OCC

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 509.61 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Liu L, Shen L, Ding Z, He M, Li E, Tallarico JA, Jain RK, Wang H. Mechanism of Resistance to the WDR5 Inhibitor in MLL-Rearranged Leukemia. ACS Chem Biol. 2023 Apr 21;18(4):949-958. doi: 10.1021/acschembio.3c00108. Epub 2023 Apr 7. PMID: 37027891.