WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130496
CAS#: NAT37-534056
Description: NAT37-534056 is an inhibitor of cAMP-dependent protein kinase A (PKA).
Hodoodo Cat#: H130496
Name: NAT37-534056
CAS#: NAT37-534056
Chemical Formula: C18H18F2N4O
Exact Mass: 344.14
Molecular Weight: 344.366
Elemental Analysis: C, 62.78; H, 5.27; F, 11.03; N, 16.27; O, 4.65
This product is not in stock, which may be available by custom synthesis.
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Synonym: NAT37 534056, NAT37 - 534056, NAT37534056
IUPAC/Chemical Name: 5-Fluoro-2-((((3S,4R)-4-fluoro-1-(pyridin-2-ylmethyl)pyrrolidin-3-yl)oxy)methyl)-1H-benzo[d]imidazole
InChi Key: HGWMMCOKQLXAIG-PBHICJAKSA-N
InChi Code: InChI=1S/C18H18F2N4O/c19-12-4-5-15-16(7-12)23-18(22-15)11-25-17-10-24(9-14(17)20)8-13-3-1-2-6-21-13/h1-7,14,17H,8-11H2,(H,22,23)/t14-,17+/m1/s1
SMILES Code: F[C@H]1[C@@H](OCC2=NC3=CC(F)=CC=C3N2)CN(CC4=NC=CC=C4)C1
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 344.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Wilson BAP, Li N, Martinez Fiesco JA, Dalilian M, Wang D, Smith EA, Wamiru A, Shah R, Goncharova EI, Beutler JA, Grkovic T, Zhang P, O'Keefe BR. Biochemical Discovery, Intracellular Evaluation, and Crystallographic Characterization of Synthetic and Natural Product Adenosine 3',5'-Cyclic Monophosphate-Dependent Protein Kinase A (PKA) Inhibitors. ACS Pharmacol Transl Sci. 2023 Mar 21;6(4):633-650. doi: 10.1021/acsptsci.3c00010. PMID: 37082750; PMCID: PMC10111623.