WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130505
CAS#: Carmaphycin-17
Description: Carmaphycin-17 is a novel anticancer proteasome inhibitor. It shows greater activity against T. vaginalis than metronidazole, overcoming metronidazole resistance, and reducing human cytotoxicity.
Hodoodo Cat#: H130505
Name: Carmaphycin-17
CAS#: Carmaphycin-17
Chemical Formula: C40H45N5O5
Exact Mass: 675.34
Molecular Weight: 675.830
Elemental Analysis: C, 71.09; H, 6.71; N, 10.36; O, 11.84
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Synonym: Carmaphycin 17, Carmaphycin - 17, Carmaphycin17
IUPAC/Chemical Name: CP-17; Hexanoyl-Trp-Trp-Phe-((S)-2-methyloxirane); N-((S)-1-(((S)-3-(1H-Indol-3-yl)-1-(((S)-1-((R)-2-methyloxiran-2-yl)-1-oxo-3-phenylpropan-2-yl)amino)-1-oxopropan-2-yl)amino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)hexanamide
InChi Key: ULJSFOJNRMFBRM-KTVNKKSOSA-N
InChi Code: InChI=1S/C40H45N5O5/c1-3-4-6-19-36(46)43-34(21-27-23-41-31-17-11-9-15-29(27)31)38(48)45-35(22-28-24-42-32-18-12-10-16-30(28)32)39(49)44-33(37(47)40(2)25-50-40)20-26-13-7-5-8-14-26/h5,7-18,23-24,33-35,41-42H,3-4,6,19-22,25H2,1-2H3,(H,43,46)(H,44,49)(H,45,48)/t33-,34-,35-,40-/m0/s1
SMILES Code: CCCCCC(N[C@H](C(N[C@@H](CC1=CNC2=C1C=CC=C2)C(N[C@@H](CC3=CC=CC=C3)C([C@@]4(C)OC4)=O)=O)=O)CC5=CNC6=C5C=CC=C6)=O
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 675.83 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. O'Donoghue AJ, Bibo-Verdugo B, Miyamoto Y, Wang SC, Yang JZ, Zuill DE, Matsuka S, Jiang Z, Almaliti J, Caffrey CR, Gerwick WH, Eckmann L. 20S Proteasome as a Drug Target in Trichomonas vaginalis. Antimicrob Agents Chemother. 2019 Oct 22;63(11):e00448-19. doi: 10.1128/AAC.00448-19. PMID: 31451503; PMCID: PMC6811414.