WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130504
CAS#: FABP3 inhibitor MF1
Description: FABP3 inhibitor MF1 is a novel FABP3 inhibitor. It suppresses D2R/FABP3 signaling, which reduced nicotine-induced CPP scores in mice.
Hodoodo Cat#: H130504
Name: FABP3 inhibitor MF1
CAS#: FABP3 inhibitor MF1
Chemical Formula: C25H21ClN2O3
Exact Mass: 432.12
Molecular Weight: 432.904
Elemental Analysis: C, 69.36; H, 4.89; Cl, 8.19; N, 6.47; O, 11.09
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Synonym: FABP3 inhibitor MF 1, FABP3 inhibitor MF-1, FABP3-In-MF1, FABP3-In-MF-1, FABP3 In MF1, Fatty Acid Binding Protein 3 Inhibitor 3, Fatty Acid Binding Protein Inhibitor-3, 4-(2-(5-(2-chlorophenyl)-1-phenyl-1H-pyrazol-3-yl)phenoxy)butanoic acid
IUPAC/Chemical Name: 4-(2-(5-(2-chlorophenyl)-1-phenyl-1H-pyrazol-3-yl)phenoxy)butanoic acid
InChi Key: ZFPJARIXQWTDSX-UHFFFAOYSA-N
InChi Code: InChI=1S/C25H21ClN2O3/c26-21-13-6-4-11-19(21)23-17-22(27-28(23)18-9-2-1-3-10-18)20-12-5-7-14-24(20)31-16-8-15-25(29)30/h1-7,9-14,17H,8,15-16H2,(H,29,30)
SMILES Code: O=C(O)CCCOC1=CC=CC=C1C2=NN(C3=CC=CC=C3)C(C4=CC=CC=C4Cl)=C2
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 432.90 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Jia W, Kawahata I, Cheng A, Sasaki T, Sasaoka T, Fukunaga K. Amelioration of Nicotine-Induced Conditioned Place Preference Behaviors in Mice by an FABP3 Inhibitor. Int J Mol Sci. 2023 Apr 2;24(7):6644. doi: 10.3390/ijms24076644. PMID: 37047614; PMCID: PMC10095245.
2. Yabuki Y, Matsuo K, Kawahata I, Fukui N, Mizobata T, Kawata Y, Owada Y, Shioda N, Fukunaga K. Fatty Acid Binding Protein 3 Enhances the Spreading and Toxicity of α-Synuclein in Mouse Brain. Int J Mol Sci. 2020 Mar 23;21(6):2230. doi: 10.3390/ijms21062230. PMID: 32210174; PMCID: PMC7139546.
3. Haga H, Yamada R, Izumi H, Shinoda Y, Kawahata I, Miyachi H, Fukunaga K. Novel fatty acid-binding protein 3 ligand inhibits dopaminergic neuronal death and improves motor and cognitive impairments in Parkinson's disease model mice. Pharmacol Biochem Behav. 2020 Apr;191:172891. doi: 10.1016/j.pbb.2020.172891. Epub 2020 Feb 29. PMID: 32126223.