WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H556335
CAS#: 1892594-93-2
Description: HS94, also known as DAPK3 inhibitor HS94, is aa dual Pim/DAPK3 inhibitor.
Hodoodo Cat#: H556335
Name: HS94
CAS#: 1892594-93-2
Chemical Formula: C15H15N5O2S
Exact Mass: 329.09
Molecular Weight: 329.378
Elemental Analysis: C, 54.70; H, 4.59; N, 21.26; O, 9.71; S, 9.73
Synonym: HS94; HS-94; HS 94; DAPK3 inhibitor HS94;
IUPAC/Chemical Name: 2-methyl-2-((4-oxo-1-phenyl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)thio)propanamide
InChi Key: HIGNONZTHOPLMQ-UHFFFAOYSA-N
InChi Code: InChI=1S/C15H15N5O2S/c1-15(2,13(16)22)23-14-18-11-10(12(21)19-14)8-17-20(11)9-6-4-3-5-7-9/h3-8H,1-2H3,(H2,16,22)(H,18,19,21)
SMILES Code: CC(SC1=NC(N(C2=CC=CC=C2)N=C3)=C3C(N1)=O)(C)C(N)=O
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 329.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
Carlson DA, Singer MR, Sutherland C, Redondo C, Alexander LT, Hughes PF, Knapp S, Gurley SB, Sparks MA, MacDonald JA, Haystead TAJ. Targeting Pim Kinases and DAPK3 to Control Hypertension. Cell Chem Biol. 2018 Oct 18;25(10):1195-1207.e32. doi: 10.1016/j.chembiol.2018.06.006. Epub 2018 Jul 19. PMID: 30033129; PMCID: PMC6863095.
