WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130500
CAS#: JAK/HDAC inhibitor 30
Description: JAK/HDAC inhibitor 30 is a novel dual JAK/HDAC inhibitor. It potentially inhibits HDAC3/6 and JAK1/2 at the nanomolar level and is selective for JAK2. It presents antiproliferative activity in both hematological malignancies and solid cancers.
Hodoodo Cat#: H130500
Name: JAK/HDAC inhibitor 30
CAS#: JAK/HDAC inhibitor 30
Chemical Formula: C28H37FN6O5S
Exact Mass: 588.25
Molecular Weight: 588.699
Elemental Analysis: C, 57.13; H, 6.34; F, 3.23; N, 14.28; O, 13.59; S, 5.45
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Synonym: JAK/HDAC inhibitor-30, JAK/HDAC In 30, JAK/HDAC-In-30, JAK/HDAC-In 30
IUPAC/Chemical Name: 7-(4-((4-((3-(N-(tert-Butyl)sulfamoyl)phenyl)amino)-5-methylpyrimidin-2-yl)amino)-2-fluorophenoxy)-N-hydroxyheptanamide
InChi Key: XQYXAGOVMRYFIS-UHFFFAOYSA-N
InChi Code: InChI=1S/C28H37FN6O5S/c1-19-18-30-27(33-26(19)31-20-10-9-11-22(16-20)41(38,39)35-28(2,3)4)32-21-13-14-24(23(29)17-21)40-15-8-6-5-7-12-25(36)34-37/h9-11,13-14,16-18,35,37H,5-8,12,15H2,1-4H3,(H,34,36)(H2,30,31,32,33)
SMILES Code: FC1=CC(NC2=NC=C(C)C(NC3=CC=CC(S(NC(C)(C)C)(=O)=O)=C3)=N2)=CC=C1OCCCCCCC(NO)=O
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 588.70 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Qiu Q, Chi F, Zhou D, Xie Z, Liu Y, Wu H, Yin Z, Shi W, Qian H. Exploration of Janus Kinase (JAK) and Histone Deacetylase (HDAC) Bispecific Inhibitors Based on the Moiety of Fedratinib for Treatment of Both Hematologic Malignancies and Solid Cancers. J Med Chem. 2023 Apr 27;66(8):5753-5773. doi: 10.1021/acs.jmedchem.3c00036. Epub 2023 Apr 14. PMID: 37057760.