WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130503
CAS#: 2828433-30-1
Description: Lactoferrin acetate is a natural globular glycoprotein of the immune system of the body and has antimicrobial activity against a wide range of microorganisms.
Hodoodo Cat#: H130503
Name: Lactoferrin acetate
CAS#: 2828433-30-1
Chemical Formula: C143H228N46O31S3
Exact Mass: 3,181.68
Molecular Weight: 3,183.868
Elemental Analysis: C, 53.95; H, 7.22; N, 20.24; O, 15.58; S, 3.02
This product is not in stock, which may be available by custom synthesis.
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Synonym: Lactoferrin-acetate
IUPAC/Chemical Name: H-Phe-Lys-Cys(1)-Arg-Arg-Trp-Gln-Trp-Arg-Met-Lys-Lys-Leu-Gly-Ala-Pro-Ser-Ile-Thr-Cys(1)-Val-Arg-Arg-Ala-Phe-OH 8 AcOH
InChi Key: VODWFGYAYSDZHD-BSKQQEKQSA-N
InChi Code: InChI=1S/C141H224N46O29S3.C2H4O2/c1-11-77(6)111-133(212)186-112(80(9)189)134(213)183-106(130(209)184-110(76(4)5)132(211)176-97(49-32-61-161-141(155)156)120(199)170-93(45-28-57-157-137(147)148)116(195)166-78(7)113(192)180-103(136(215)216)66-82-36-16-13-17-37-82)74-219-218-73-105(182-123(202)90(42-22-25-54-142)167-114(193)87(145)65-81-34-14-12-15-35-81)129(208)173-95(47-30-59-159-139(151)152)118(197)171-96(48-31-60-160-140(153)154)122(201)178-102(68-84-70-163-89-41-21-19-39-86(84)89)127(206)174-98(51-52-108(146)190)124(203)179-101(67-83-69-162-88-40-20-18-38-85(83)88)126(205)172-94(46-29-58-158-138(149)150)119(198)175-99(53-63-217-10)125(204)169-91(43-23-26-55-143)117(196)168-92(44-24-27-56-144)121(200)177-100(64-75(2)3)115(194)164-71-109(191)165-79(8)135(214)187-62-33-50-107(187)131(210)181-104(72-188)128(207)185-111;1-2(3)4/h12-21,34-41,69-70,75-80,87,90-107,110-112,162-163,188-189H,11,22-33,42-68,71-74,142-145H2,1-10H3,(H2,146,190)(H,164,194)(H,165,191)(H,166,195)(H,167,193)(H,168,196)(H,169,204)(H,170,199)(H,171,197)(H,172,205)(H,173,208)(H,174,206)(H,175,198)(H,176,211)(H,177,200)(H,178,201)(H,179,203)(H,180,192)(H,181,210)(H,182,202)(H,183,213)(H,184,209)(H,185,207)(H,186,212)(H,215,216)(H4,147,148,157)(H4,149,150,158)(H4,151,152,159)(H4,153,154,160)(H4,155,156,161);1H3,(H,3,4)/t77-,78-,79-,80+,87-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,110-,111-,112-;/m0./s1
SMILES Code: CC[C@@H]([C@H]1C(N[C@@H]([C@H](O)C)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)CC2=CC=CC=C2)=O)C)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)C(C)C)=O)CSSC[C@H](NC([C@@H](NC([C@@H](N)CC3=CC=CC=C3)=O)CCCCN)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC4=CNC5=CC=CC=C54)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC6=CNC7=CC=CC=C76)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCSC)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(NCC(N[C@@H](C)C(N8CCC[C@H]8C(N[C@@H](CO)C(N1)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C.CC(O)=O
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 3,183.87 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1. Kaczyńska K, Jampolska M, Wojciechowski P, Sulejczak D, Andrzejewski K, Zając D. Potential of Lactoferrin in the Treatment of Lung Diseases. Pharmaceuticals (Basel). 2023 Jan 28;16(2):192. doi: 10.3390/ph16020192. PMID: 37259341.
2. Masson PL, Heremans JF, Ferin J. Presence of an Iron-binding protein (lactoferrin) in the genital tract of the human female. I. Its immunohistochemical localization in the endometrium. Fertil Steril. 1968 Sep-Oct;19(5):679-89. doi: 10.1016/s0015-0282(16)36781-4. PMID: 4877677.
3. Masson P, Heremans JF, Prignot J. Immunohistochemical localization of the iron-binding protein lactoferrin in human bronchial glands. Experientia. 1965 Oct 15;21(10):604-5. doi: 10.1007/BF02151559. PMID: 5330250.
4. Yamauchi K, Wakabayashi H, Shin K, Takase M. Bovine lactoferrin: benefits and mechanism of action against infections. Biochem Cell Biol. 2006 Jun;84(3):291-6. doi: 10.1139/o06-054. PMID: 16936799.
5. Legrand D, Elass E, Carpentier M, Mazurier J. Interactions of lactoferrin with cells involved in immune function. Biochem Cell Biol. 2006 Jun;84(3):282-90. doi: 10.1139/o06-045. PMID: 16936798.
6. Takayama Y, Takezawa T. Lactoferrin promotes collagen gel contractile activity of fibroblasts mediated by lipoprotein receptors. Biochem Cell Biol. 2006 Jun;84(3):268-74. doi: 10.1139/o06-041. PMID: 16936796.
7. Saraceno R, Gramiccia T, Chimenti S, Valenti P, Pietropaoli M, Bianchi L. Topical lactoferrin can improve stable psoriatic plaque. G Ital Dermatol Venereol. 2014 Jun;149(3):335-40. PMID: 24819761.
8. Chella Krishnan K, Mukundan S, Landero Figueroa JA, Caruso JA, Kotb M. Metal-mediated modulation of streptococcal cysteine protease activity and its biological implications. Infect Immun. 2014 Jul;82(7):2992-3001. doi: 10.1128/IAI.01770-14. Epub 2014 May 5. PMID: 24799625; PMCID: PMC4097633.
9. Montesi M, Panseri S, Iafisco M, Adamiano A, Tampieri A. Coupling Hydroxyapatite Nanocrystals with Lactoferrin as a Promising Strategy to Fine Regulate Bone Homeostasis. PLoS One. 2015 Jul 6;10(7):e0132633. doi: 10.1371/journal.pone.0132633. PMID: 26148296; PMCID: PMC4492779.
10. Coussens AK, Wilkinson RJ, Martineau AR. Phenylbutyrate Is Bacteriostatic against Mycobacterium tuberculosis and Regulates the Macrophage Response to Infection, Synergistically with 25-Hydroxy-Vitamin D3. PLoS Pathog. 2015 Jul 2;11(7):e1005007. doi: 10.1371/journal.ppat.1005007. PMID: 26133770; PMCID: PMC4489717.
