ALDH1A3 inhibitor NR6

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H130513

CAS#: 2703797-37-7

Description: ALDH1A3 inhibitor NR6 is a novel, potent, and highly selective ALDH1A3 inhibitor. It impairs mesothelioma multicellular spheroid growth and neutrophil recruitment.

Chemical Structure

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ALDH1A3 inhibitor NR6
CAS# 2703797-37-7
Instruction

Theoretical Analysis

Hodoodo Cat#: H130513
Name: ALDH1A3 inhibitor NR6
CAS#: 2703797-37-7
Chemical Formula: C20H13N3
Exact Mass: 295.11
Molecular Weight: 295.350
Elemental Analysis: C, 81.34; H, 4.44; N, 14.23

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: NR6, ALDH1A3 In NR6, ALDH1A3-In-NR6, ALDH1A3 inhibitor-NR6, ALDH1A3 In-NR6, ALDH1A3-In NR6

IUPAC/Chemical Name: 3-(2-Phenylimidazo[1,2-a]pyridin-6-yl)benzenecarbonitrile

InChi Key: ZIPMVBBAKJZVIG-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H13N3/c21-12-15-5-4-8-17(11-15)18-9-10-20-22-19(14-23(20)13-18)16-6-2-1-3-7-16/h1-11,13-14H

SMILES Code: N#CC1=CC=CC(C2=CN3C(C=C2)=NC(C4=CC=CC=C4)=C3)=C1

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 295.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Boumya S, Fallarini S, Siragusa S, Petrarolo G, Aprile S, Audrito V, La Motta C, Garavaglia S, Moro L, Pinton G. A Selective ALDH1A3 Inhibitor Impairs Mesothelioma 3-D Multicellular Spheroid Growth and Neutrophil Recruitment. Int J Mol Sci. 2023 Apr 3;24(7):6689. doi: 10.3390/ijms24076689. PMID: 37047661; PMCID: PMC10094992.

2. Gelardi ELM, Colombo G, Picarazzi F, Ferraris DM, Mangione A, Petrarolo G, Aronica E, Rizzi M, Mori M, La Motta C, Garavaglia S. A Selective Competitive Inhibitor of Aldehyde Dehydrogenase 1A3 Hinders Cancer Cell Growth, Invasiveness and Stemness In Vitro. Cancers (Basel). 2021 Jan 19;13(2):356. doi: 10.3390/cancers13020356. PMID: 33478031; PMCID: PMC7835878.