WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H556342
CAS#: 2893967-40-1
Description: BE1218 is a liver X receptor (LXR) inverse agonist..
Hodoodo Cat#: H556342
Name: BE1218
CAS#: 2893967-40-1
Chemical Formula: C30H30FNO4S2
Exact Mass: 551.16
Molecular Weight: 551.691
Elemental Analysis: C, 65.31; H, 5.48; F, 3.44; N, 2.54; O, 11.60; S, 11.62
Synonym: BE1218; BE-1218; BE 1218;
IUPAC/Chemical Name: N-(2-fluorobenzyl)-2,4,6-trimethyl-N-((3'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl)methyl)benzenesulfonamide
InChi Key: YZKNHPOMZOAMSW-UHFFFAOYSA-N
InChi Code: InChI=1S/C30H30FNO4S2/c1-21-16-22(2)30(23(3)17-21)38(35,36)32(20-27-8-5-6-11-29(27)31)19-24-12-14-25(15-13-24)26-9-7-10-28(18-26)37(4,33)34/h5-18H,19-20H2,1-4H3
SMILES Code: CC1=CC(C)=C(C(C)=C1)S(=O)(N(CC2=C(C=CC=C2)F)CC3=CC=C(C=C3)C4=CC(S(C)(=O)=O)=CC=C4)=O
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 551.69 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
Elgendy B, Griffett K, Hegazy L, Di Fruscia P, Sample K, Schoepke E, Kamenecka TM, Burris TP. Synthesis and structure activity relationship of the first class of LXR inverse agonists. Bioorg Chem. 2022 Feb;119:105540. doi: 10.1016/j.bioorg.2021.105540. Epub 2021 Dec 7. PMID: 34902646.