WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130518
CAS#: KTT-1
Description: KTT-1 is a novel histone deacetylase 2 (HDAC2) inhibitor. It displays kinetically selective inhibition of HDAC2 over HDAC1.
Hodoodo Cat#: H130518
Name: KTT-1
CAS#: KTT-1
Chemical Formula: C26H21N5O4S
Exact Mass: 499.13
Molecular Weight: 499.545
Elemental Analysis: C, 62.51; H, 4.24; N, 14.02; O, 12.81; S, 6.42
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Synonym: KTT 1, KTT1
IUPAC/Chemical Name: N-(2-Amino-5-(furan-2-yl)phenyl)-4-(1-((phenylsulfonyl)methyl)-1H-1,2,3-triazol-4-yl)benzamide
InChi Key: XCJIKXQBHOGKHC-UHFFFAOYSA-N
InChi Code: InChI=1S/C26H21N5O4S/c27-22-13-12-20(25-7-4-14-35-25)15-23(22)28-26(32)19-10-8-18(9-11-19)24-16-31(30-29-24)17-36(33,34)21-5-2-1-3-6-21/h1-16H,17,27H2,(H,28,32)
SMILES Code: O=C(NC1=CC(C2=CC=CO2)=CC=C1N)C3=CC=C(C4=CN(CS(=O)(C5=CC=CC=C5)=O)N=N4)C=C3
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 499.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Mishima H, Itoh Y, Kurohara T, Suzuki T, Asada N, Kusakabe KI, Okamoto Y. Origin of the kinetic HDAC2-selectivity of an HDAC inhibitor. J Comput Chem. 2023 Jul 5;44(18):1604-1609. doi: 10.1002/jcc.27111. Epub 2023 Apr 19. PMID: 37074817.