Biofilm inhibitor 2B5

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Hodoodo CAT#: H130519

CAS#: Biofilm inhibitor 2B5

Description: Biofilm inhibitor 2B5 is a novel and potent inhibitor of S. mutans biofilms (IC50 of 1.9 μM), targeting VicR, a key response regulator in S. mutans and S. aureus.

Chemical Structure

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Biofilm inhibitor 2B5
CAS# Biofilm inhibitor 2B5
Instruction

Theoretical Analysis

Hodoodo Cat#: H130519
Name: Biofilm inhibitor 2B5
CAS#: Biofilm inhibitor 2B5
Chemical Formula: C23H45ClN4O
Exact Mass: 428.33
Molecular Weight: 429.090
Elemental Analysis: C, 64.38; H, 10.57; Cl, 8.26; N, 13.06; O, 3.73

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Biofilm inhibitor-2B5, Biofilm-In-2B5, Biofilm In 2B5, 2B5, Biofilm 2B5, Biofilm-2B5

IUPAC/Chemical Name: 4-(2-Amino-1H-imidazol-4-yl)-N-hexadecylbutanamide hydrochloride

InChi Key: CTERFFVFQKDASL-UHFFFAOYSA-N

InChi Code: InChI=1S/C23H44N4O.ClH/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-19-25-22(28)18-16-17-21-20-26-23(24)27-21;/h20H,2-19H2,1H3,(H,25,28)(H3,24,26,27);1H

SMILES Code: O=C(NCCCCCCCCCCCCCCCC)CCCC1=CNC(N)=N1.[H]Cl

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 429.09 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Liu C, Zhang H, Peng X, Blackledge MS, Furlani RE, Li H, Su Z, Melander RJ, Melander C, Michalek S, Wu H. Small Molecule Attenuates Bacterial Virulence by Targeting Conserved Response Regulator. mBio. 2023 Apr 19:e0013723. doi: 10.1128/mbio.00137-23. Epub ahead of print. PMID: 37074183.

2. Liu C, Worthington RJ, Melander C, Wu H. A new small molecule specifically inhibits the cariogenic bacterium Streptococcus mutans in multispecies biofilms. Antimicrob Agents Chemother. 2011 Jun;55(6):2679-87. doi: 10.1128/AAC.01496-10. Epub 2011 Mar 14. PMID: 21402858; PMCID: PMC3101470.