WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130528
CAS#: Dihydrotrichodimerol
Description: Dihydrotrichodimerol is derived from Penicillium terrestre, acting as a dual PPARα/γ agonist with cytotoxic activities against P388 and A-549 cell lines.
Hodoodo Cat#: H130528
Name: Dihydrotrichodimerol
CAS#: Dihydrotrichodimerol
Chemical Formula: C28H34O8
Exact Mass: 498.23
Molecular Weight: 498.570
Elemental Analysis: C, 67.45; H, 6.87; O, 25.67
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Related CAS #: 145174-90-9
Synonym: dihydrotrichodimerol
IUPAC/Chemical Name: (2R,3S,4aR,5R,7Z,8R,8aS,9R,11Z)-2,4a-dihydroxy-7-((E)-1-hydroxyhex-4-en-1-ylidene)-11-((2E,4E)-1-hydroxyhexa-2,4-dien-1-ylidene)-3,5,8a,9-tetramethylhexahydro-2,8,3,5-(epibutane[1,1,4,4]tetrayl)benzo[b][1,4]dioxine-6,10(5H)-dione
InChi Key: VXNANBMCYPZBSM-DDMJHHNASA-N
InChi Code: InChI=1S/C28H34O8/c1-7-9-11-13-15(29)17-19-23(3)22(32)18(16(30)14-12-10-8-2)20-24(4,21(17)31)28(34)25(19,5)35-27(23,33)26(20,6)36-28/h7-11,13,19-20,29,32-34H,12,14H2,1-6H3/b9-7+,10-8+,13-11+,17-15-/t19?,20?,23-,24-,25+,26+,27-,28-/m1/s1
SMILES Code: O=C1[C@]2(C)[C@@]3(O)O[C@@]4(C)C2C(C(CC/C=C/C)=O)=C(O)[C@]5(C)[C@@]4(O)O[C@@]3(C)C5/C1=C(O)\C=C\C=C\C
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 498.57 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Liu J, Gao S, Zhou W, Chen Y, Wang Z, Zeng Z, Zhou H, Lin T. Dihydrotrichodimerol Purified from the Marine Fungus Acremonium citrinum Prevents NAFLD by Targeting PPARα. J Nat Prod. 2023 May 26;86(5):1189-1201. doi: 10.1021/acs.jnatprod.2c00990. Epub 2023 Apr 21. PMID: 37083418.
2. Balde ES, Andolfi A, Bruyère C, Cimmino A, Lamoral-Theys D, Vurro M, Damme MV, Altomare C, Mathieu V, Kiss R, Evidente A. Investigations of fungal secondary metabolites with potential anticancer activity. J Nat Prod. 2010 May 28;73(5):969-71. doi: 10.1021/np900731p. PMID: 20415482.
3. Evidente A, Andolfi A, Cimmino A, Ganassi S, Altomare C, Favilla M, De Cristofaro A, Vitagliano S, Agnese Sabatini M. Bisorbicillinoids produced by the fungus Trichoderma citrinoviride affect feeding preference of the aphid Schizaphis graminum. J Chem Ecol. 2009 May;35(5):533-41. doi: 10.1007/s10886-009-9632-6. Epub 2009 May 6. PMID: 19418099.
4. Liu W, Gu Q, Zhu W, Cui C, Fan G. Dihydrotrichodimerol and tetrahydrotrichodimerol, two new bisorbicillinoids, from a marine-derived Penicillium terrestre. J Antibiot (Tokyo). 2005 Oct;58(10):621-4. doi: 10.1038/ja.2005.85. PMID: 16392677.
5. Lee D, Lee JH, Cai XF, Shin JC, Lee K, Hong YS, Lee JJ. Fungal metabolites, sorbicillinoid polyketides and their effects on the activation of peroxisome proliferator-activated receptor gamma. J Antibiot (Tokyo). 2005 Oct;58(10):615-20. doi: 10.1038/ja.2005.84. PMID: 16392676.