DK2403

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Hodoodo CAT#: H130521

CAS#: DK2403

Description: DK2403 is a novel, highly potent, and selective covalent inhibitor of MAP2K7 (also known as MEK7 and MKK7).

Chemical Structure

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DK2403
CAS# DK2403
Instruction

Theoretical Analysis

Hodoodo Cat#: H130521
Name: DK2403
CAS#: DK2403
Chemical Formula: C19H17ClN4O2
Exact Mass: 368.10
Molecular Weight: 368.821
Elemental Analysis: C, 61.88; H, 4.65; Cl, 9.61; N, 15.19; O, 8.68

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: DK 2403, DK-2403, MAP2K7 Inhibitor DK2403, MEK7 Inhibitor DK2403, MKK7 Inhibitor DK2403, MAP2K7-In-DK2403, MEK7-In-DK2403, MKK7-In-DK2403, MAP2K7 In DK2403, MEK7 In DK2403, MKK7 In DK2403

IUPAC/Chemical Name: N-(3-((6-(Benzylamino)pyrimidin-4-yl)oxy)phenyl)-2-chloroacetamide

InChi Key: SWAPCFYOLJWGBA-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H17ClN4O2/c20-11-18(25)24-15-7-4-8-16(9-15)26-19-10-17(22-13-23-19)21-12-14-5-2-1-3-6-14/h1-10,13H,11-12H2,(H,24,25)(H,21,22,23)

SMILES Code: O=C(NC1=CC=CC(OC2=NC=NC(NCC3=CC=CC=C3)=C2)=C1)CCl

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 368.82 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Kim DR, Orr MJ, Kwong AJ, Deibler KK, Munshi HH, Bridges CS, Chen TJ, Zhang X, Lacorazza HD, Scheidt KA. Rational Design of Highly Potent and Selective Covalent MAP2K7 Inhibitors. ACS Med Chem Lett. 2023 Apr 17;14(5):606-613. doi: 10.1021/acsmedchemlett.3c00029. PMID: 37197477; PMCID: PMC10184151.