P2Y6R antagonist 50

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H130520

CAS#: P2Y6R antagonist 50

Description: P2Y6R antagonist 50 is a novel potent and selective P2Y6R antagonist (IC50 = 5.914 nM). It ameliorates DSS-induced ulcerative colitis in mice by inhibiting NLRP3 inflammasome activation in colon tissues.

Chemical Structure

img
P2Y6R antagonist 50
CAS# P2Y6R antagonist 50
Instruction

Theoretical Analysis

Hodoodo Cat#: H130520
Name: P2Y6R antagonist 50
CAS#: P2Y6R antagonist 50
Chemical Formula: C18H17ClN4O
Exact Mass: 340.11
Molecular Weight: 340.811
Elemental Analysis: C, 63.44; H, 5.03; Cl, 10.40; N, 16.44; O, 4.69

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: P2Y6R antagonist-50, P2Y6R-Ant-50, P2Y6R-Antag-50, P2Y6R-AA-50, P2Y6R-AN-50, P2Y6R-AT-50, P2Y6R Ant 50, P2Y6R Antag 50, P2Y6R AA 50, P2Y6R AN 50, P2Y6R AT 50

IUPAC/Chemical Name: 2-(1-(tert-Butyl)-5-(furan-2-yl)-1H-pyrazol-3-yl)-5-chloro-1H-benzo[d]imidazole

InChi Key: MDMLYQRLSMYAKZ-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H17ClN4O/c1-18(2,3)23-15(16-5-4-8-24-16)10-14(22-23)17-20-12-7-6-11(19)9-13(12)21-17/h4-10H,1-3H3,(H,20,21)

SMILES Code: ClC1=CC=C2NC(C3=NN(C(C)(C)C)C(C4=CC=CO4)=C3)=NC2=C1

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 340.81 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1. Zhu Y, Zhou M, Cheng X, Wang H, Li Y, Guo Y, Wang Y, Tian S, Mao T, Zhang Z, Li D, Hu Q, Li H. Discovery of Selective P2Y6R Antagonists with High Affinity and In Vivo Efficacy for Inflammatory Disease Therapy. J Med Chem. 2023 May 11;66(9):6315-6332. doi: 10.1021/acs.jmedchem.3c00210. Epub 2023 Apr 20. PMID: 37078976.