Ac-His-d-Phe-Arg-Aia

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Hodoodo CAT#: H130563

CAS#: Ac-His-d-Phe-Arg-Aia

Description: Ac-His-d-Phe-Arg-Aia is a novel, potent, and selective agonist of human melanocortin 1 receptor (hMC1R). It has an EC50 of 11.2 nM for hMC1R and at least 15-fold selectivity compared to other MCR subtypes.

Chemical Structure

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Ac-His-d-Phe-Arg-Aia
CAS# Ac-His-d-Phe-Arg-Aia
Instruction

Theoretical Analysis

Hodoodo Cat#: H130563
Name: Ac-His-d-Phe-Arg-Aia
CAS#: Ac-His-d-Phe-Arg-Aia
Chemical Formula: C35H43N11O5
Exact Mass: 697.34
Molecular Weight: 697.800
Elemental Analysis: C, 60.24; H, 6.21; N, 22.08; O, 11.46

Price and Availability

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Synonym: Ac His d Phe Arg Aia

IUPAC/Chemical Name: (S)-2-((R)-2-((S)-2-Acetamido-3-(1H-imidazol-4-yl)propanamido)-3-phenylpropanamido)-5-guanidino-N-((S)-3-oxo-1,2,3,4,5,10-hexahydroazepino[3,4-b]indol-4-yl)pentanamide

InChi Key: YKAWDEHFCQNJSK-CRNKYVSFSA-N

InChi Code: InChI=1S/C35H43N11O5/c1-20(47)42-28(15-22-17-38-19-41-22)34(51)45-27(14-21-8-3-2-4-9-21)33(50)44-26(12-7-13-39-35(36)37)32(49)46-29-16-24-23-10-5-6-11-25(23)43-30(24)18-40-31(29)48/h2-6,8-11,17,19,26-29,43H,7,12-16,18H2,1H3,(H,38,41)(H,40,48)(H,42,47)(H,44,50)(H,45,51)(H,46,49)(H4,36,37,39)/t26-,27+,28-,29-/m0/s1

SMILES Code: O=C(N[C@H]1CC2=C(CNC1=O)NC3=C2C=CC=C3)[C@@H](NC([C@H](NC([C@@H](NC(C)=O)CC4=CNC=N4)=O)CC5=CC=CC=C5)=O)CCCNC(N)=N

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 697.80 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Zhou Y, Mowlazadeh Haghighi S, Sawyer JR, Hruby VJ, Cai M. Ψ and χ Angle Constrains at the C-Terminus Trp Position of the Melanotropin Tetrapeptide Ac-His-d-Phe-Arg-Trp-NH2 Lead to Potent and Selective Agonists at hMC1R and hMC4R. J Med Chem. 2023 May 25;66(10):6715-6724. doi: 10.1021/acs.jmedchem.2c01794. Epub 2023 May 3. PMID: 37133411.