WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130539
CAS#: AT2R inhibitor A-174
Description: AT2R inhibitor A-174 is a novel inhibitor of the angiotensin II type 2 receptor (AT2R). It is being investigated as a non-opioid approach to treating neuropathic pain.
Hodoodo Cat#: H130539
Name: AT2R inhibitor A-174
CAS#: AT2R inhibitor A-174
Chemical Formula: C21H27FN8
Exact Mass: 410.23
Molecular Weight: 410.501
Elemental Analysis: C, 61.44; H, 6.63; F, 4.63; N, 27.30
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Synonym: AT2R In A-174, AT2R inhibitor A174, AT2R inhibitor A 174, AT2R In A174, AT2R-In-A-174, AT2RInA174
IUPAC/Chemical Name: (S)-3-((4-(3-Fluoro-5-isobutyl-2-(2H-tetrazol-5-yl)phenyl)-2-methylpiperazin-1-yl)methyl)pyridazine
InChi Key: BHRGLVGWNMTDFE-HNNXBMFYSA-N
InChi Code: InChI=1S/C21H27FN8/c1-14(2)9-16-10-18(22)20(21-25-27-28-26-21)19(11-16)30-8-7-29(15(3)12-30)13-17-5-4-6-23-24-17/h4-6,10-11,14-15H,7-9,12-13H2,1-3H3,(H,25,26,27,28)/t15-/m0/s1
SMILES Code: C[C@@H]1N(CC2=NN=CC=C2)CCN(C3=CC(CC(C)C)=CC(F)=C3C4=NNN=N4)C1
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 410.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Balogh M, Aguilar C, Nguyen NT, Shepherd AJ. Angiotensin receptors and neuropathic pain. Pain Rep. 2021 Mar 9;6(1):e869. doi: 10.1097/PR9.0000000000000869. PMID: 33981922; PMCID: PMC8108581.