WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130545
CAS#: C1s inhibitor (R)-8
Description: C1s inhibitor (R)-8 is a novel, potent, selective, orally available, and brain-penetrable C1s inhibitor for modulation of the complement pathway.
Hodoodo Cat#: H130545
Name: C1s inhibitor (R)-8
CAS#: C1s inhibitor (R)-8
Chemical Formula: C22H20F2N6O
Exact Mass: 422.17
Molecular Weight: 422.440
Elemental Analysis: C, 62.55; H, 4.77; F, 8.99; N, 19.89; O, 3.79
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Synonym: C1s inhibitor R-8, C1s inhibitor (R)8,C1s inhibitor R-8, C1s In R-8, C1s In (R)8, C1s In R-8, C1s inhibitor (R)-8
IUPAC/Chemical Name: (R)-8-Fluoro-6-(4-(3-fluorophenyl)-3-(5-methylisoxazol-3-yl)piperazin-1-yl)phthalazin-1-amine
InChi Key: HXAFDSAENALNGM-HXUWFJFHSA-N
InChi Code: InChI=1S/C22H20F2N6O/c1-13-7-19(28-31-13)20-12-29(5-6-30(20)16-4-2-3-15(23)9-16)17-8-14-11-26-27-22(25)21(14)18(24)10-17/h2-4,7-11,20H,5-6,12H2,1H3,(H2,25,27)/t20-/m1/s1
SMILES Code: NC1=NN=CC2=C1C(F)=CC(N3C[C@H](C4=NOC(C)=C4)N(C5=CC=CC(F)=C5)CC3)=C2
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 422.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Ikeda Z, Kamei T, Sasaki Y, Reynolds M, Sakai N, Yoshikawa M, Tawada M, Morishita N, Dougan DR, Chen CH, Levin I, Zou H, Kuno M, Arimura N, Kikukawa Y, Kondo M, Tohyama K, Sato K. Discovery of a Novel Series of Potent, Selective, Orally Available, and Brain-Penetrable C1s Inhibitors for Modulation of the Complement Pathway. J Med Chem. 2023 May 11;66(9):6354-6371. doi: 10.1021/acs.jmedchem.3c00348. Epub 2023 Apr 25. PMID: 37120845; PMCID: PMC10184130.