Caspase-6 inhibitor 3a

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Hodoodo CAT#: H130552

CAS#: Caspase-6 inhibitor 3a

Description: Caspase-6 inhibitor 3a is a novel, irreversible, potent, and selective inhibitor of caspase-6.

Chemical Structure

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Caspase-6 inhibitor 3a
CAS# Caspase-6 inhibitor 3a
Instruction

Theoretical Analysis

Hodoodo Cat#: H130552
Name: Caspase-6 inhibitor 3a
CAS#: Caspase-6 inhibitor 3a
Chemical Formula: C21H21F3N2O4S
Exact Mass: 454.12
Molecular Weight: 454.460
Elemental Analysis: C, 55.50; H, 4.66; F, 12.54; N, 6.16; O, 14.08; S, 7.05

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Caspase6 inhibitor 3a, Caspase 6 inhibitor 3a, Caspase-6 In 3a, Caspase6 In 3a, Caspase 6 In 3a, Caspase-6-In-3a, Caspase6-In-3a, C6 inhibitor 3a, C6 In 3a, C6-In-3a C6-inhibitor-3a

IUPAC/Chemical Name: (3R,5S)-5-Phenyl-N-(4-(trifluoromethoxy)phenyl)-1-(vinylsulfonyl)piperidine-3-carboxamide

InChi Key: ZPJPZBJLIIKUPK-IAGOWNOFSA-N

InChi Code: InChI=1S/C21H21F3N2O4S/c1-2-31(28,29)26-13-16(15-6-4-3-5-7-15)12-17(14-26)20(27)25-18-8-10-19(11-9-18)30-21(22,23)24/h2-11,16-17H,1,12-14H2,(H,25,27)/t16-,17-/m1/s1

SMILES Code: O=C([C@H]1CN(S(=O)(C=C)=O)C[C@H](C2=CC=CC=C2)C1)NC3=CC=C(OC(F)(F)F)C=C3

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 454.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Van Horn KS, Wang D, Medina-Cleghorn D, Lee PS, Bryant C, Altobelli C, Jaishankar P, Leung KK, Ng RA, Ambrose AJ, Tang Y, Arkin MR, Renslo AR. Engaging a Non-catalytic Cysteine Residue Drives Potent and Selective Inhibition of Caspase-6. J Am Chem Soc. 2023 May 10;145(18):10015-10021. doi: 10.1021/jacs.2c12240. Epub 2023 Apr 27. PMID: 37104712; PMCID: PMC10176470.