WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H13542
CAS#: D347-2761
Description: D347-2761 is a novel dual-targeting c-Myc inhibitor. It represses myeloma growth via blocking c-Myc/Max heterodimerization and disturbing its stability.
Hodoodo Cat#: H13542
Name: D347-2761
CAS#: D347-2761
Chemical Formula: C28H29N3O2
Exact Mass: 439.23
Molecular Weight: 439.560
Elemental Analysis: C, 76.51; H, 6.65; N, 9.56; O, 7.28
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Synonym: D3472761, D347 2761
IUPAC/Chemical Name: 4-{1-[2-(3,5-Dimethylphenoxy)ethyl]-1H-benzimidazol-2-yl}-1-(3-methylphenyl)pyrrolidin-2-one
InChi Key: FDHXXENNNGTWEV-UHFFFAOYSA-N
InChi Code: InChI=1S/C28H29N3O2/c1-19-7-6-8-23(14-19)31-18-22(17-27(31)32)28-29-25-9-4-5-10-26(25)30(28)11-12-33-24-15-20(2)13-21(3)16-24/h4-10,13-16,22H,11-12,17-18H2,1-3H3
SMILES Code: O=C1N(C2=CC=CC(C)=C2)CC(C3=NC4=CC=CC=C4N3CCOC5=CC(C)=CC(C)=C5)C1
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 439.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Yao R, Zhang M, Zhou J, Liu L, Zhang Y, Gao J, Xu K. Novel dual-targeting c-Myc inhibitor D347-2761 represses myeloma growth via blocking c-Myc/Max heterodimerization and disturbing its stability. Cell Commun Signal. 2022 May 26;20(1):73. doi: 10.1186/s12964-022-00868-6. PMID: 35619182; PMCID: PMC9137135.