DS44960156

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H130555

CAS#: 2361327-08-2

Description: DS44960156 is a substrate site inhibitor of MTHFD2 with an IC50 value of 1.6 μM and >18 fold selectivity over MTHFD1.

Chemical Structure

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DS44960156
CAS# 2361327-08-2
Instruction

Theoretical Analysis

Hodoodo Cat#: H130555
Name: DS44960156
CAS#: 2361327-08-2
Chemical Formula: C20H15NO5
Exact Mass: 349.10
Molecular Weight: 349.340
Elemental Analysis: C, 68.76; H, 4.33; N, 4.01; O, 22.90

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: DS 44960156, DS-44960156

IUPAC/Chemical Name: 4-(5-Oxo-1,3,4,5-tetrahydro-2H-chromeno[3,4-c]pyridine-3-carbonyl)benzoic acid

InChi Key: OXUKTNZACAKVRG-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H15NO5/c22-18(12-5-7-13(8-6-12)19(23)24)21-10-9-14-15-3-1-2-4-17(15)26-20(25)16(14)11-21/h1-8H,9-11H2,(H,23,24)

SMILES Code: O=C(O)C1=CC=C(C(N2CCC(C3=C(O4)C=CC=C3)=C(C4=O)C2)=O)C=C1

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 349.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Kawai J, Ota M, Ohki H, Toki T, Suzuki M, Shimada T, Matsui S, Inoue H, Sugihara C, Matsuhashi N, Matsui Y, Takaishi S, Nakayama K. Structure-Based Design and Synthesis of an Isozyme-Selective MTHFD2 Inhibitor with a Tricyclic Coumarin Scaffold. ACS Med Chem Lett. 2019 May 24;10(6):893-898. doi: 10.1021/acsmedchemlett.9b00069. PMID: 31223444; PMCID: PMC6580548.